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    Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms

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    Type
    Article
    Authors
    Li, Yong Xin
    Wu, Hui Xian
    Xu, Ying
    Shao, Chang Lun
    Wang, Chang Yun
    Qian, Pei-Yuan cc
    KAUST Grant Number
    SA-C0040
    UK-C001
    Date
    2013-04-25
    Permanent link to this record
    http://hdl.handle.net/10754/600215
    
    Metadata
    Show full item record
    Abstract
    Biofouling results in tremendous economic losses to maritime industries around the world. A recent global ban on the use of organotin compounds as antifouling agents has further raised demand for safe and effective antifouling compounds. In this study, 49 secondary metabolites, including diterpenoids, steroids, and polyketides, were isolated from soft corals, gorgonians, brown algae, and fungi collected along the coast of China, and their antifouling activity was tested against cyprids of the barnacle Balanus (Amphibalanus) amphitrite. Twenty of the compounds were found to inhibit larval settlement significantly at a concentration of 25 μg ml-1. Two briarane diterpenoids, juncin O (2) and juncenolide H (3), were the most promising non-toxic antilarval settlement candidates, with EC50 values less than 0.13 μg ml-1 and a safety ratio (LC50/EC50) higher than 400. A preliminary structure-activity relationships study indicated that both furanon and furan moieties are important for antifouling activity. Intriguingly, the presence of hydroxyls enhanced their antisettlement activity. © 2013 Springer Science+Business Media New York.
    Citation
    Li Y-X, Wu H-X, Xu Y, Shao C-L, Wang C-Y, et al. (2013) Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms. Mar Biotechnol 15: 552–558. Available: http://dx.doi.org/10.1007/s10126-013-9502-7.
    Sponsors
    This study was supported by a research grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, a joint research grant from the Research Grants Council of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China (N_HKUST602/09 and No. 41130858), and an award (SA-C0040/UK-C001) from King Abdullah University of Science and Technology (KAUST) granted to P.Y. Qian.
    Publisher
    Springer Nature
    Journal
    Marine Biotechnology
    DOI
    10.1007/s10126-013-9502-7
    PubMed ID
    23613141
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10126-013-9502-7
    Scopus Count
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