Validity of the Cauchy-Born rule applied to discrete cellular-scale models of biological tissues
KAUST Grant NumberKUK-C1-013-04
MetadataShow full item record
AbstractThe development of new models of biological tissues that consider cells in a discrete manner is becoming increasingly popular as an alternative to continuum methods based on partial differential equations, although formal relationships between the discrete and continuum frameworks remain to be established. For crystal mechanics, the discrete-to-continuum bridge is often made by assuming that local atom displacements can be mapped homogeneously from the mesoscale deformation gradient, an assumption known as the Cauchy-Born rule (CBR). Although the CBR does not hold exactly for noncrystalline materials, it may still be used as a first-order approximation for analytic calculations of effective stresses or strain energies. In this work, our goal is to investigate numerically the applicability of the CBR to two-dimensional cellular-scale models by assessing the mechanical behavior of model biological tissues, including crystalline (honeycomb) and noncrystalline reference states. The numerical procedure involves applying an affine deformation to the boundary cells and computing the quasistatic position of internal cells. The position of internal cells is then compared with the prediction of the CBR and an average deviation is calculated in the strain domain. For center-based cell models, we show that the CBR holds exactly when the deformation gradient is relatively small and the reference stress-free configuration is defined by a honeycomb lattice. We show further that the CBR may be used approximately when the reference state is perturbed from the honeycomb configuration. By contrast, for vertex-based cell models, a similar analysis reveals that the CBR does not provide a good representation of the tissue mechanics, even when the reference configuration is defined by a honeycomb lattice. The paper concludes with a discussion of the implications of these results for concurrent discrete and continuous modeling, adaptation of atom-to-continuum techniques to biological tissues, and model classification. © 2013 American Physical Society.
CitationDavit Y, Osborne JM, Byrne HM, Gavaghan D, Pitt-Francis J (2013) Validity of the Cauchy-Born rule applied to discrete cellular-scale models of biological tissues. Phys Rev E 87. Available: http://dx.doi.org/10.1103/PhysRevE.87.042724.
SponsorsThis work was based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
PublisherAmerican Physical Society (APS)
JournalPhysical Review E
CollectionsPublications Acknowledging KAUST Support
- Computation of the effective mechanical response of biological networks accounting for large configuration changes.
- Authors: El Nady K, Ganghoffer JF
- Issue date: 2016 May
- Comparison between spring network models and continuum constitutive laws: application to the large deformation of a capsule in shear flow.
- Authors: Omori T, Ishikawa T, Barthès-Biesel D, Salsac AV, Walter J, Imai Y, Yamaguchi T
- Issue date: 2011 Apr
- A new extension of cauchy-born rule for monolayer crystal films.
- Authors: Lu S, Cho C
- Issue date: 2010 Mar 23
- Modeling biological tissue growth: discrete to continuum representations.
- Authors: Hywood JD, Hackett-Jones EJ, Landman KA
- Issue date: 2013 Sep