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dc.contributor.authorSiva Tian, Tian
dc.contributor.authorHuang, Jianhua Z.
dc.contributor.authorShen, Haipeng
dc.date.accessioned2016-02-28T06:42:57Z
dc.date.available2016-02-28T06:42:57Z
dc.date.issued2013-12-11
dc.identifier.citationSiva Tian T, Huang JZ, Shen H (2013) Two-way regularization for MEG source reconstruction via multilevel coordinate descent. Statistical Analy Data Mining 6: 545–556. Available: http://dx.doi.org/10.1002/sam.11210.
dc.identifier.issn1932-1864
dc.identifier.doi10.1002/sam.11210
dc.identifier.urihttp://hdl.handle.net/10754/600114
dc.description.abstractMagnetoencephalography (MEG) source reconstruction refers to the inverse problem of recovering the neural activity from the MEG time course measurements. A spatiotemporal two-way regularization (TWR) method was recently proposed by Tian et al. to solve this inverse problem and was shown to outperform several one-way regularization methods and spatiotemporal methods. This TWR method is a two-stage procedure that first obtains a raw estimate of the source signals and then refines the raw estimate to ensure spatial focality and temporal smoothness using spatiotemporal regularized matrix decomposition. Although proven to be effective, the performance of two-stage TWR depends on the quality of the raw estimate. In this paper we directly solve the MEG source reconstruction problem using a multivariate penalized regression where the number of variables is much larger than the number of cases. A special feature of this regression is that the regression coefficient matrix has a spatiotemporal two-way structure that naturally invites a two-way penalty. Making use of this structure, we develop a computationally efficient multilevel coordinate descent algorithm to implement the method. This new one-stage TWR method has shown its superiority to the two-stage TWR method in three simulation studies with different levels of complexity and a real-world MEG data analysis. © 2013 Wiley Periodicals, Inc., A Wiley Company.
dc.description.sponsorshipThis work was supported in part by NCI (CA57030), NSF (DMS-09-07170, DMS-10-07618, CMMI-0800575, DMS-11-06912, DMS-12-08952, and DMS-12-08786), NIDA (1 RC1 DA029425-01), and King Abdullah University of Science and Technology (KUS-CI-016-04).
dc.publisherWiley
dc.subjectCoordinate descent
dc.subjectInverse problem
dc.subjectSpatiotemporal
dc.subjectTwo-way regularization
dc.titleTwo-way regularization for MEG source reconstruction via multilevel coordinate descent
dc.typeArticle
dc.identifier.journalStatistical Analysis and Data Mining
dc.contributor.institutionUniversity of Houston, Houston, United States
dc.contributor.institutionTexas A and M University, College Station, United States
dc.contributor.institutionThe University of North Carolina at Chapel Hill, Chapel Hill, United States
kaust.grant.numberKUS-CI-016-04
dc.date.published-online2013-12-11
dc.date.published-print2013-12


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