Toward a quantitative understanding of the Wnt/ β -catenin pathway through simulation and experiment
Type
ArticleKAUST Grant Number
KUK-013-04Date
2013-03-29Online Publication Date
2013-03-29Print Publication Date
2013-07Permanent link to this record
http://hdl.handle.net/10754/600044
Metadata
Show full item recordAbstract
Wnt signaling regulates cell survival, proliferation, and differentiation throughout development and is aberrantly regulated in cancer. The pathway is activated when Wnt ligands bind to specific receptors on the cell surface, resulting in the stabilization and nuclear accumulation of the transcriptional co-activator β-catenin. Mathematical and computational models have been used to study the spatial and temporal regulation of the Wnt/β-catenin pathway and to investigate the functional impact of mutations in key components. Such models range in complexity, from time-dependent, ordinary differential equations that describe the biochemical interactions between key pathway components within a single cell, to complex, multiscale models that incorporate the role of the Wnt/β-catenin pathway target genes in tissue homeostasis and carcinogenesis. This review aims to summarize recent progress in mathematical modeling of the Wnt pathway and to highlight new biological results that could form the basis for future theoretical investigations designed to increase the utility of theoretical models of Wnt signaling in the biomedical arena. © 2013 Wiley Periodicals, Inc.Citation
Lloyd-Lewis B, Fletcher AG, Dale TC, Byrne HM (2013) Toward a quantitative understanding of the Wnt/ β -catenin pathway through simulation and experiment . Wiley Interdisciplinary Reviews: Systems Biology and Medicine 5: 391–407. Available: http://dx.doi.org/10.1002/wsbm.1221.Sponsors
AGF is supported by EPRSC (EP/I017909/1) and Microsoft Research, Cambridge. This publication was based on work supported in part by Award No. KUK-013-04, made by King Abdullah University of Science and Technology (KAUST). BLL was supported by Cancer Research UK. TCD was supported by Cancer Research UK, the Breast Cancer Campaign and Tenovus.Publisher
WileyPubMed ID
23554326ae974a485f413a2113503eed53cd6c53
10.1002/wsbm.1221
Scopus Count
Collections
Publications Acknowledging KAUST SupportRelated articles
- Context-dependent regulation of the β-catenin transcriptional complex supports diverse functions of Wnt/β-catenin signaling.
- Authors: Masuda T, Ishitani T
- Issue date: 2017 Jan
- Genomic insights into WNT/β-catenin signaling.
- Authors: Rosenbluh J, Wang X, Hahn WC
- Issue date: 2014 Feb
- The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics.
- Authors: Vargas DA, Sun M, Sadykov K, Kukuruzinska MA, Zaman MH
- Issue date: 2016 Jul
- Wnt signaling in development and tissue homeostasis.
- Authors: Steinhart Z, Angers S
- Issue date: 2018 Jun 8
- Wnt/beta-catenin signaling: components, mechanisms, and diseases.
- Authors: MacDonald BT, Tamai K, He X
- Issue date: 2009 Jul