Theory for the alignment of cortical feature maps during development
Type
ArticleKAUST Grant Number
KUK-C1-013-4Date
2010-08-23Permanent link to this record
http://hdl.handle.net/10754/599985
Metadata
Show full item recordAbstract
We present a developmental model of ocular dominance column formation that takes into account the existence of an array of intrinsically specified cytochrome oxidase blobs. We assume that there is some molecular substrate for the blobs early in development, which generates a spatially periodic modulation of experience-dependent plasticity. We determine the effects of such a modulation on a competitive Hebbian mechanism for the modification of the feedforward afferents from the left and right eyes. We show how alternating left and right eye dominated columns can develop, in which the blobs are aligned with the centers of the ocular dominance columns and receive a greater density of feedforward connections, thus becoming defined extrinsically. More generally, our results suggest that the presence of periodically distributed anatomical markers early in development could provide a mechanism for the alignment of cortical feature maps. © 2010 The American Physical Society.Citation
Bressloff PC, Oster AM (2010) Theory for the alignment of cortical feature maps during development. Phys Rev E 82. Available: http://dx.doi.org/10.1103/PhysRevE.82.021920.Sponsors
This paper was based on work supported in part by the NSF (Grant No. DMS-0209824) and by Award No. KUK-C1-013-4 made by the King Abdullah University of Science and Technology (KAUST). P.C.B. was also partially supported by the Royal Society-Wolfson Foundation, and A.M.O. was partially supported by the Neuropole de Recherche Francilien (NeRF) and an ANR MNP 'Dopanic' grant.Publisher
American Physical Society (APS)Journal
Physical Review EPubMed ID
20866850ae974a485f413a2113503eed53cd6c53
10.1103/PhysRevE.82.021920
Scopus Count
Collections
Publications Acknowledging KAUST SupportRelated articles
- Theoretical and experimental studies of relationship between pinwheel centers and ocular dominance columns in the visual cortex.
- Authors: Nakagama H, Tani T, Tanaka S
- Issue date: 2006 Aug
- A developmental model of ocular dominance column formation on a growing cortex.
- Authors: Oster AM, Bressloff PC
- Issue date: 2006 Jan
- Neural pattern formation via a competitive Hebbian mechanism.
- Authors: Obermayer K, Sejnowski T, Blasdel GG
- Issue date: 1995 Jan 23
- Pinwheel stabilization by ocular dominance segregation.
- Authors: Reichl L, Löwel S, Wolf F
- Issue date: 2009 May 22
- A laminar model for the joint development of ocular dominance columns and CO blobs in the primary visual cortex.
- Authors: Oster AM
- Issue date: 2023 Sep 7