The Influence of Receptor-Mediated Interactions on Reaction-Diffusion Mechanisms of Cellular Self-organisation
KAUST Grant NumberKUK-C1-013-04
MetadataShow full item record
AbstractUnderstanding the mechanisms governing and regulating self-organisation in the developing embryo is a key challenge that has puzzled and fascinated scientists for decades. Since its conception in 1952 the Turing model has been a paradigm for pattern formation, motivating numerous theoretical and experimental studies, though its verification at the molecular level in biological systems has remained elusive. In this work, we consider the influence of receptor-mediated dynamics within the framework of Turing models, showing how non-diffusing species impact the conditions for the emergence of self-organisation. We illustrate our results within the framework of hair follicle pre-patterning, showing how receptor interaction structures can be constrained by the requirement for patterning, without the need for detailed knowledge of the network dynamics. Finally, in the light of our results, we discuss the ability of such systems to pattern outside the classical limits of the Turing model, and the inherent dangers involved in model reduction. © 2011 Society for Mathematical Biology.
CitationKlika V, Baker RE, Headon D, Gaffney EA (2011) The Influence of Receptor-Mediated Interactions on Reaction-Diffusion Mechanisms of Cellular Self-organisation. Bull Math Biol 74: 935–957. Available: http://dx.doi.org/10.1007/s11538-011-9699-4.
SponsorsThis publication was based on work supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). One of the authors (V.K.) is grateful for the hospitality of the Oxford Centre for Collaborative Applied Mathematics and the Institute for Mathematics and Its Applications during work on this project, as well as for many helpful comments and collaborations from his colleagues.
JournalBulletin of Mathematical Biology
CollectionsPublications Acknowledging KAUST Support
- Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse.
- Authors: Cheng CW, Niu B, Warren M, Pevny LH, Lovell-Badge R, Hwa T, Cheah KS
- Issue date: 2014 Feb 18
- The role of trans-membrane signal transduction in turing-type cellular pattern formation.
- Authors: Rauch EM, Millonas MM
- Issue date: 2004 Feb 21
- Hierarchical patterning modes orchestrate hair follicle morphogenesis.
- Authors: Glover JD, Wells KL, Matthäus F, Painter KJ, Ho W, Riddell J, Johansson JA, Ford MJ, Jahoda CAB, Klika V, Mort RL, Headon DJ
- Issue date: 2017 Jul
- Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).
- Authors: Foffi G, Pastore A, Piazza F, Temussi PA
- Issue date: 2013 Aug 2
- The dynamics of Turing patterns for morphogen-regulated growing domains with cellular response delays.
- Authors: Seirin Lee S, Gaffney EA, Baker RE
- Issue date: 2011 Nov