The Influence of Gene Expression Time Delays on Gierer–Meinhardt Pattern Formation Systems
KAUST Grant NumberKUK-C1-013-04
Online Publication Date2010-03-23
Print Publication Date2010-11
Permanent link to this recordhttp://hdl.handle.net/10754/599921
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AbstractThere are numerous examples of morphogen gradients controlling long range signalling in developmental and cellular systems. The prospect of two such interacting morphogens instigating long range self-organisation in biological systems via a Turing bifurcation has been explored, postulated, or implicated in the context of numerous developmental processes. However, modelling investigations of cellular systems typically neglect the influence of gene expression on such dynamics, even though transcription and translation are observed to be important in morphogenetic systems. In particular, the influence of gene expression on a large class of Turing bifurcation models, namely those with pure kinetics such as the Gierer-Meinhardt system, is unexplored. Our investigations demonstrate that the behaviour of the Gierer-Meinhardt model profoundly changes on the inclusion of gene expression dynamics and is sensitive to the sub-cellular details of gene expression. Features such as concentration blow up, morphogen oscillations and radical sensitivities to the duration of gene expression are observed and, at best, severely restrict the possible parameter spaces for feasible biological behaviour. These results also indicate that the behaviour of Turing pattern formation systems on the inclusion of gene expression time delays may provide a means of distinguishing between possible forms of interaction kinetics. Finally, this study also emphasises that sub-cellular and gene expression dynamics should not be simply neglected in models of long range biological pattern formation via morphogens. © 2010 Society for Mathematical Biology.
CitationSeirin Lee S, Gaffney EA, Monk NAM (2010) The Influence of Gene Expression Time Delays on Gierer–Meinhardt Pattern Formation Systems. Bull Math Biol 72: 2139–2160. Available: http://dx.doi.org/10.1007/s11538-010-9532-5.
SponsorsThis publication is based on work supported in part by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). SSL would like to thank Professor PK Maini and The Centre for Mathematical Biology for warm hospitality and a visiting position as well as gratefully acknowledging funding from the Japan Society for the Promotion of Science (JSPS Fellowship DC1).
JournalBulletin of Mathematical Biology
CollectionsPublications Acknowledging KAUST Support
- The dynamics of Turing patterns for morphogen-regulated growing domains with cellular response delays.
- Authors: Seirin Lee S, Gaffney EA, Baker RE
- Issue date: 2011 Nov
- Aberrant behaviours of reaction diffusion self-organisation models on growing domains in the presence of gene expression time delays.
- Authors: Seirin Lee S, Gaffney EA
- Issue date: 2010 Nov
- Induction and the Turing-Child field in development.
- Authors: Schiffmann Y
- Issue date: 2005 Sep
- The sensitivity of Turing self-organization to biological feedback delays: 2D models of fish pigmentation.
- Authors: Gaffney EA, Lee SS
- Issue date: 2015 Mar
- Gene expression time delays and Turing pattern formation systems.
- Authors: Gaffney EA, Monk NA
- Issue date: 2006 Jan