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    The Influence of Gene Expression Time Delays on Gierer–Meinhardt Pattern Formation Systems

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    Type
    Article
    Authors
    Seirin Lee, S.
    Gaffney, E. A.
    Monk, N. A. M.
    KAUST Grant Number
    KUK-C1-013-04
    Date
    2010-03-23
    Online Publication Date
    2010-03-23
    Print Publication Date
    2010-11
    Permanent link to this record
    http://hdl.handle.net/10754/599921
    
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    Abstract
    There are numerous examples of morphogen gradients controlling long range signalling in developmental and cellular systems. The prospect of two such interacting morphogens instigating long range self-organisation in biological systems via a Turing bifurcation has been explored, postulated, or implicated in the context of numerous developmental processes. However, modelling investigations of cellular systems typically neglect the influence of gene expression on such dynamics, even though transcription and translation are observed to be important in morphogenetic systems. In particular, the influence of gene expression on a large class of Turing bifurcation models, namely those with pure kinetics such as the Gierer-Meinhardt system, is unexplored. Our investigations demonstrate that the behaviour of the Gierer-Meinhardt model profoundly changes on the inclusion of gene expression dynamics and is sensitive to the sub-cellular details of gene expression. Features such as concentration blow up, morphogen oscillations and radical sensitivities to the duration of gene expression are observed and, at best, severely restrict the possible parameter spaces for feasible biological behaviour. These results also indicate that the behaviour of Turing pattern formation systems on the inclusion of gene expression time delays may provide a means of distinguishing between possible forms of interaction kinetics. Finally, this study also emphasises that sub-cellular and gene expression dynamics should not be simply neglected in models of long range biological pattern formation via morphogens. © 2010 Society for Mathematical Biology.
    Citation
    Seirin Lee S, Gaffney EA, Monk NAM (2010) The Influence of Gene Expression Time Delays on Gierer–Meinhardt Pattern Formation Systems. Bull Math Biol 72: 2139–2160. Available: http://dx.doi.org/10.1007/s11538-010-9532-5.
    Sponsors
    This publication is based on work supported in part by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). SSL would like to thank Professor PK Maini and The Centre for Mathematical Biology for warm hospitality and a visiting position as well as gratefully acknowledging funding from the Japan Society for the Promotion of Science (JSPS Fellowship DC1).
    Publisher
    Springer Nature
    Journal
    Bulletin of Mathematical Biology
    DOI
    10.1007/s11538-010-9532-5
    PubMed ID
    20309645
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11538-010-9532-5
    Scopus Count
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