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dc.contributor.authorKimpton, L. S.
dc.contributor.authorWhiteley, J. P.
dc.contributor.authorWaters, S. L.
dc.contributor.authorOliver, J. M.
dc.date.accessioned2016-02-28T06:32:05Z
dc.date.available2016-02-28T06:32:05Z
dc.date.issued2014-07-23
dc.identifier.citationKimpton LS, Whiteley JP, Waters SL, Oliver JM (2014) The effect of membrane-regulated actin polymerization on a two-phase flow model for cell motility. IMA Journal of Applied Mathematics 79: 603–635. Available: http://dx.doi.org/10.1093/imamat/hxu035.
dc.identifier.issn0272-4960
dc.identifier.issn1464-3634
dc.identifier.doi10.1093/imamat/hxu035
dc.identifier.urihttp://hdl.handle.net/10754/599903
dc.description.abstractTwo-phase flow models have been widely used to model cell motility and we have previously demonstrated that even the simplest, stripped-down, 1D model displays many observed features of cell motility [Kimpton, L.S., Whiteley, J.P., Waters, S.L., King, J.R. & Oliver, J.M. (2013) Multiple travelling-wave solutions in a minimal model for cell motility. Math. Med. Biol. 30, 241 - 272]. In this paper, we address a limitation of the previous model.We show that the two-phase flow framework can exhibit travelling-wave solutions with biologically plausible actin network profiles in two simple models that enforce polymerization or depolymerization of the actin network at the ends of the travelling, 1D strip of cytoplasm. © 2014 The authors 2014. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.
dc.description.sponsorshipThis publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). S. L. W. is grateful for funding from the EPSRC in the form of an Advanced Research Fellowship.
dc.publisherOxford University Press (OUP)
dc.subjectactin polymerization
dc.subjectcell membrane
dc.subjectcell motility
dc.subjecttwo-phase flow
dc.titleThe effect of membrane-regulated actin polymerization on a two-phase flow model for cell motility
dc.typeArticle
dc.identifier.journalIMA Journal of Applied Mathematics
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdom
kaust.grant.numberKUK-C1-013-04
dc.date.published-online2014-07-23
dc.date.published-print2014-08-01


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