AuthorsDay, Joshua J.
McFadden, Ryan M.
Virgil, Scott C.
Alleva, Jennifer L.
Stoltz, Brian M.
KAUST Grant NumberKUS-11-006-02
Permanent link to this recordhttp://hdl.handle.net/10754/599884
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AbstractRing a ding: The meroterpenoid natural product (+)-liphagal has been synthesized enantioselectively in 19 steps from commercially available materials. The trans-homodecalin system was achieved by ring expansion followed by stereoselective hydrogenation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
CitationDay JJ, McFadden RM, Virgil SC, Kolding H, Alleva JL, et al. (2011) The Catalytic Enantioselective Total Synthesis of (+)-Liphagal. Angew Chem Int Ed 50: 6814–6818. Available: http://dx.doi.org/10.1002/anie.201101842.
SponsorsThis publication is based on work supported by Award No. KUS-11-006-02, made by the King Abdullah University of Science and Technology (KAUST). We wish to thank the NIH-NIGMS (R01M080269-01), the Gordon and Betty Moore Foundation, Abbott, Amgen, Boehringer Ingelheim, and Caltech for generous funding. R.M.M. thanks Eli Lilly for a graduate fellowship. H.K. acknowledges the travelling scholarship of the Danish Technical University, the Jorcks foundation, and the Otto Mønsteds foundation for financial support. J.L.A. gratefully acknowledges the Amgen Foundation for funding through the Amgen Scholars program. We thank Prof. E. N. Jacobsen and Dr. S. J. Zuend for a kind donation of both (R)-t-leucine and their optimal Strecker catalyst.
PubMed Central IDPMC3361906