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dc.contributor.authorZhang, Ning
dc.contributor.authorPompe, Tilo
dc.contributor.authorAmin, Ihsan
dc.contributor.authorLuxenhofer, Robert
dc.contributor.authorWerner, Carsten
dc.contributor.authorJordan, Rainer
dc.date.accessioned2016-02-28T06:31:03Z
dc.date.available2016-02-28T06:31:03Z
dc.date.issued2012-05-18
dc.identifier.citationZhang N, Pompe T, Amin I, Luxenhofer R, Werner C, et al. (2012) Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion. Macromolecular Bioscience 12: 926–936. Available: http://dx.doi.org/10.1002/mabi.201200026.
dc.identifier.issn1616-5187
dc.identifier.pmid22610725
dc.identifier.doi10.1002/mabi.201200026
dc.identifier.urihttp://hdl.handle.net/10754/599859
dc.description.abstractPOx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.sponsorshipN.Z. is thankful for support by the CompInt (International Graduate School of complex interface) of the TU Munchen through a Ph.D. fellowship. R.J. is thankful for further support by the IGSSE (International Graduate School for Science and Engineering). R.J. and C.W. acknowledge support by the Center for Regenerative Therapies Dresden (CRTD). R.L. is thankful for a postdoctoral fellowship of the King Abdullah University of Science and Technology (KAUST, Award. No. KUK-F1-029-32). The authors thank Kati Mittasch and Juliane Drichel for technical support in protein adsorption and cell culture experiments.
dc.publisherWiley
dc.subjectCell adhesion
dc.subjectPolymer brushes
dc.subjectPolyoxazolines
dc.subjectProtein adsorption
dc.subjectSurface-initiated polymerization
dc.titleTailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion
dc.typeArticle
dc.identifier.journalMacromolecular Bioscience
dc.contributor.institutionTechnische Universitat Munchen, Munich, Germany
dc.contributor.institutionLeibniz-Institut fur Polymerforschung Dresden e.V., Dresden, Germany
dc.contributor.institutionUniversitat Leipzig, Leipzig, Germany
dc.contributor.institutionTechnische Universitat Dresden, Dresden, Germany
dc.contributor.institutionCenter for Regenerative Therapies Dresden, Dresden, Germany
kaust.grant.numberKUK-F1-029-32
dc.date.published-online2012-05-18
dc.date.published-print2012-07


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