Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion
KAUST Grant NumberKUK-F1-029-32
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AbstractPOx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
CitationZhang N, Pompe T, Amin I, Luxenhofer R, Werner C, et al. (2012) Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion. Macromolecular Bioscience 12: 926–936. Available: http://dx.doi.org/10.1002/mabi.201200026.
SponsorsN.Z. is thankful for support by the CompInt (International Graduate School of complex interface) of the TU Munchen through a Ph.D. fellowship. R.J. is thankful for further support by the IGSSE (International Graduate School for Science and Engineering). R.J. and C.W. acknowledge support by the Center for Regenerative Therapies Dresden (CRTD). R.L. is thankful for a postdoctoral fellowship of the King Abdullah University of Science and Technology (KAUST, Award. No. KUK-F1-029-32). The authors thank Kati Mittasch and Juliane Drichel for technical support in protein adsorption and cell culture experiments.
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