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    Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters

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    Type
    Article
    Authors
    Burlakov, V. M.
    Emptage, N.
    Goriely, A.
    Bressloff, P. C.
    KAUST Grant Number
    KUK-C1-013-04
    Date
    2012-01-10
    Permanent link to this record
    http://hdl.handle.net/10754/599827
    
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    Abstract
    We introduce a bistability mechanism for long-term synaptic plasticity based on switching between two metastable states that contain significantly different numbers of synaptic receptors. One state is characterized by a two-dimensional gas of mobile interacting receptors and is stabilized against clustering by a high nucleation barrier. The other state contains a receptor gas in equilibrium with a large cluster of immobile receptors, which is stabilized by the turnover rate of receptors into and out of the synapse. Transitions between the two states can be initiated by either an increase (potentiation) or a decrease (depotentiation) of the net receptor flux into the synapse. This changes the saturation level of the receptor gas and triggers nucleation or evaporation of receptor clusters. © 2012 American Physical Society.
    Citation
    Burlakov VM, Emptage N, Goriely A, Bressloff PC (2012) Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters. Physical Review Letters 108. Available: http://dx.doi.org/10.1103/physrevlett.108.028101.
    Sponsors
    This work was funded by the John Fell Oxford University Press (OUP) Research Fund. In part, it was also supported by King Abdullah University of Science and Technology Award No. KUK-C1-013-04. A. G. and P. C. B. were supported by Wolfson/Royal Society Merit Awards. N. E. thanks the Medical Research Council (UK) for support.
    Publisher
    American Physical Society (APS)
    Journal
    Physical Review Letters
    DOI
    10.1103/physrevlett.108.028101
    PubMed ID
    22324711
    ae974a485f413a2113503eed53cd6c53
    10.1103/physrevlett.108.028101
    Scopus Count
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