Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters
KAUST Grant NumberKUK-C1-013-04
Permanent link to this recordhttp://hdl.handle.net/10754/599827
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AbstractWe introduce a bistability mechanism for long-term synaptic plasticity based on switching between two metastable states that contain significantly different numbers of synaptic receptors. One state is characterized by a two-dimensional gas of mobile interacting receptors and is stabilized against clustering by a high nucleation barrier. The other state contains a receptor gas in equilibrium with a large cluster of immobile receptors, which is stabilized by the turnover rate of receptors into and out of the synapse. Transitions between the two states can be initiated by either an increase (potentiation) or a decrease (depotentiation) of the net receptor flux into the synapse. This changes the saturation level of the receptor gas and triggers nucleation or evaporation of receptor clusters. © 2012 American Physical Society.
CitationBurlakov VM, Emptage N, Goriely A, Bressloff PC (2012) Synaptic Bistability Due to Nucleation and Evaporation of Receptor Clusters. Physical Review Letters 108. Available: http://dx.doi.org/10.1103/physrevlett.108.028101.
SponsorsThis work was funded by the John Fell Oxford University Press (OUP) Research Fund. In part, it was also supported by King Abdullah University of Science and Technology Award No. KUK-C1-013-04. A. G. and P. C. B. were supported by Wolfson/Royal Society Merit Awards. N. E. thanks the Medical Research Council (UK) for support.
PublisherAmerican Physical Society (APS)
JournalPhysical Review Letters