• Login
    View Item 
    •   Home
    • Office of Sponsored Research (OSR)
    • KAUST Funded Research
    • Publications Acknowledging KAUST Support
    • View Item
    •   Home
    • Office of Sponsored Research (OSR)
    • KAUST Funded Research
    • Publications Acknowledging KAUST Support
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguideTheses and Dissertations LibguideSubmit an Item

    Statistics

    Display statistics

    Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD)

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Type
    Article
    Authors
    Quitterer, Felix
    Beck, Philipp
    Bacher, Adelbert
    Groll, Michael
    KAUST Grant Number
    FIC/2010/07
    Date
    2013-05-29
    Online Publication Date
    2013-05-29
    Print Publication Date
    2013-07-01
    Permanent link to this record
    http://hdl.handle.net/10754/599762
    
    Metadata
    Show full item record
    Abstract
    The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase. This catalyzed reaction includes an induced-fit mechanism achieved by major structural rearrangements of the N-terminal helix upon substrate binding. Different steps of the reaction trajectory are visualized by complex structures of PylD with substrate and product. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Citation
    Quitterer F, Beck P, Bacher A, Groll M (2013) Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD). Angew Chem Int Ed 52: 7033–7037. Available: http://dx.doi.org/10.1002/anie.201301164.
    Sponsors
    We thank the staff of the beamline X06SA at the Paul Scherrer Institute, Swiss Light Source, Villigen (Switzerland) for their help with data collection and Katrin Gartner for excellent technical assistance. We acknowledge Dr. Anja List who participated in the PylD project. This work was supported by the Hans-Fischer-Gesellschaft, by Award No. FIC/2010/07 from the King Abdullah University of Science and Technology (KAUST), and by the Deutsche Forschungsgemeinschaft (DFG, grant GR1861/7-1).
    Publisher
    Wiley
    Journal
    Angewandte Chemie
    DOI
    10.1002/anie.201301164
    PubMed ID
    23720358
    ae974a485f413a2113503eed53cd6c53
    10.1002/anie.201301164
    Scopus Count
    Collections
    Publications Acknowledging KAUST Support

    entitlement

    Related articles

    • The formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD).
    • Authors: Quitterer F, Beck P, Bacher A, Groll M
    • Issue date: 2014 Jul 28
    • D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine.
    • Authors: Cellitti SE, Ou W, Chiu HP, Grünewald J, Jones DH, Hao X, Fan Q, Quinn LL, Ng K, Anfora AT, Lesley SA, Uno T, Brock A, Geierstanger BH
    • Issue date: 2011 Apr 27
    • Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system.
    • Authors: Gattner MJ, Vrabel M, Carell T
    • Issue date: 2013 Jan 14
    • Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
    • Authors: Krzycki JA
    • Issue date: 2004 Oct
    • Reactivity and chemical synthesis of L-pyrrolysine- the 22(nd) genetically encoded amino acid.
    • Authors: Hao B, Zhao G, Kang PT, Soares JA, Ferguson TK, Gallucci J, Krzycki JA, Chan MK
    • Issue date: 2004 Sep
    DSpace software copyright © 2002-2023  DuraSpace
    Quick Guide | Contact Us | KAUST University Library
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.