Show simple item record

dc.contributor.authorChailyan, Anna
dc.contributor.authorMarcatili, Paolo
dc.contributor.authorCirillo, Davide
dc.contributor.authorTramontano, Anna
dc.date.accessioned2016-02-28T06:09:08Z
dc.date.available2016-02-28T06:09:08Z
dc.date.issued2011-03-01
dc.identifier.citationChailyan A, Marcatili P, Cirillo D, Tramontano A (2011) Structural repertoire of immunoglobulin λ light chains. Proteins: Structure, Function, and Bioinformatics 79: 1513–1524. Available: http://dx.doi.org/10.1002/prot.22979.
dc.identifier.issn0887-3585
dc.identifier.pmid21365679
dc.identifier.doi10.1002/prot.22979
dc.identifier.urihttp://hdl.handle.net/10754/599758
dc.description.abstractThe immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions, contrary to what is the case for κ and heavy chains. We show here that an analysis of the structures of λ chains allows the definition of a discrete set of recurring conformations (canonical structures) of their hypervariable loops and, most importantly, the identification of sequence constraints that can be used to predict their structure. We also show that the structural repertoire of λ chains is different and more varied than that of the κ chains, consistently with the current view of the involvement of the two major light-chain families in complementary strategies of the immune system to ensure a fine tuning between diversity and stability in antigen recognition. © 2011 Wiley-Liss, Inc.
dc.description.sponsorshipGrant sponsor: King Abdullah University of Science and Technology (KAUST); Grant number: KUK-I1-012-43; Grant sponsor: Ministero della Salute; Grant number: RF-IDI-2006-354931; Grant sponsor: FIRB Italbionet and Proteomica
dc.publisherWiley
dc.subjectCanonical structures
dc.subjectImmunoglobulins
dc.subjectLambda chains
dc.titleStructural repertoire of immunoglobulin λ light chains
dc.typeArticle
dc.identifier.journalProteins: Structure, Function, and Bioinformatics
dc.contributor.institutionUniversita degli Studi di Roma La Sapienza, Rome, Italy
kaust.grant.numberKUK-I1-012-43
dc.date.published-online2011-03-01
dc.date.published-print2011-05


This item appears in the following Collection(s)

Show simple item record