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    Structural repertoire of immunoglobulin λ light chains

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    Type
    Article
    Authors
    Chailyan, Anna
    Marcatili, Paolo
    Cirillo, Davide
    Tramontano, Anna
    KAUST Grant Number
    KUK-I1-012-43
    Date
    2011-03-01
    Online Publication Date
    2011-03-01
    Print Publication Date
    2011-05
    Permanent link to this record
    http://hdl.handle.net/10754/599758
    
    Metadata
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    Abstract
    The immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions, contrary to what is the case for κ and heavy chains. We show here that an analysis of the structures of λ chains allows the definition of a discrete set of recurring conformations (canonical structures) of their hypervariable loops and, most importantly, the identification of sequence constraints that can be used to predict their structure. We also show that the structural repertoire of λ chains is different and more varied than that of the κ chains, consistently with the current view of the involvement of the two major light-chain families in complementary strategies of the immune system to ensure a fine tuning between diversity and stability in antigen recognition. © 2011 Wiley-Liss, Inc.
    Citation
    Chailyan A, Marcatili P, Cirillo D, Tramontano A (2011) Structural repertoire of immunoglobulin λ light chains. Proteins: Structure, Function, and Bioinformatics 79: 1513–1524. Available: http://dx.doi.org/10.1002/prot.22979.
    Sponsors
    Grant sponsor: King Abdullah University of Science and Technology (KAUST); Grant number: KUK-I1-012-43; Grant sponsor: Ministero della Salute; Grant number: RF-IDI-2006-354931; Grant sponsor: FIRB Italbionet and Proteomica
    Publisher
    Wiley
    Journal
    Proteins: Structure, Function, and Bioinformatics
    DOI
    10.1002/prot.22979
    PubMed ID
    21365679
    ae974a485f413a2113503eed53cd6c53
    10.1002/prot.22979
    Scopus Count
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