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dc.contributor.authorZhou, Xiaojian
dc.contributor.authorXu, Ying
dc.contributor.authorJin, Cuili
dc.contributor.authorQian, Pei-Yuan
dc.date.accessioned2016-02-28T05:52:25Z
dc.date.available2016-02-28T05:52:25Z
dc.date.issued2009-07-24
dc.identifier.citationZhou X, Xu Y, Jin C, Qian P-Y (2009) Reversible anti-settlement activity against Amphibalanus (= Balanus ) amphitrite, Bugula neritina , and Hydroides elegans by a nontoxic pharmaceutical compound, mizolastine . Biofouling 25: 739–747. Available: http://dx.doi.org/10.1080/08927010903154724.
dc.identifier.issn0892-7014
dc.identifier.issn1029-2454
dc.identifier.pmid20183132
dc.identifier.doi10.1080/08927010903154724
dc.identifier.urihttp://hdl.handle.net/10754/599506
dc.description.abstractMizolastine, an antihistamine pharmaceutical, was found to significantly inhibit larval settlement of the barnacle Amphibalanus (=Balanus) amphitrite, the bryozoan Bugula neritina, and the polychaete Hydroides elegans with EC50 values of 4.2, 11.2, and 4.1 mg ml-1, respectively. No toxicity against the larvae of these three species was observed at the concentration range tested during incubations with mizolastine. To determine whether the anti-settlement activity of mizolastine is reversible, recovery bioassays using these three species were conducted. More than 70% of the larvae that had been exposed for 4 h to mizolastine at concentrations four-fold greater than their respective EC50 values completed normal metamorphosis. The results of the recovery bioassay provide evidence that the antisettlement effect of mizolastine is reversible in addition to being nontoxic. The anti-settlement activities of several intermediates of the synthesis process of mizolastine were also examined. One of the intermediates, 2-chloro-1-(4- fluorobenzyl)-1H-benzo[d]imidazole, inhibited larval settlement and metamorphosis with low toxicity. These results may improve the understanding of the key functional group responsible for the anti-settlement activity of mizolastine. © 2009 Taylor & Francis.
dc.description.sponsorshipThis study was supported by a grant from the Chinese Ocean Mineral Resources Research and Development Association (COMAR06/07.SC02), and the CAS/SAFEA International Partnership Program for Creative Research Teams as well as a research fund from KAUST International Partnership Program (KAUST005-CML.07/08) to Qian P.-Y.
dc.publisherInforma UK Limited
dc.subjectAmphibalanus (=Balanus) amphitrite
dc.subjectAnti-settlement activity
dc.subjectBugula neritina
dc.subjectHydroides elegans
dc.subjectLarvae
dc.subjectMizolastine
dc.titleReversible anti-settlement activity against Amphibalanus (= Balanus ) amphitrite, Bugula neritina , and Hydroides elegans by a nontoxic pharmaceutical compound, mizolastine
dc.typeArticle
dc.identifier.journalBiofouling
dc.contributor.institutionYangzhou University, Yangzhou, China
dc.contributor.institutionHong Kong University of Science and Technology, Hong Kong, China
kaust.grant.numberKAUST005-CML.07/08
dc.date.published-online2009-07-24
dc.date.published-print2009-11


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