Reversible anti-settlement activity against Amphibalanus (= Balanus ) amphitrite, Bugula neritina , and Hydroides elegans by a nontoxic pharmaceutical compound, mizolastine
Type
ArticleKAUST Grant Number
KAUST005-CML.07/08Date
2009-07-24Online Publication Date
2009-07-24Print Publication Date
2009-11Permanent link to this record
http://hdl.handle.net/10754/599506
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Mizolastine, an antihistamine pharmaceutical, was found to significantly inhibit larval settlement of the barnacle Amphibalanus (=Balanus) amphitrite, the bryozoan Bugula neritina, and the polychaete Hydroides elegans with EC50 values of 4.2, 11.2, and 4.1 mg ml-1, respectively. No toxicity against the larvae of these three species was observed at the concentration range tested during incubations with mizolastine. To determine whether the anti-settlement activity of mizolastine is reversible, recovery bioassays using these three species were conducted. More than 70% of the larvae that had been exposed for 4 h to mizolastine at concentrations four-fold greater than their respective EC50 values completed normal metamorphosis. The results of the recovery bioassay provide evidence that the antisettlement effect of mizolastine is reversible in addition to being nontoxic. The anti-settlement activities of several intermediates of the synthesis process of mizolastine were also examined. One of the intermediates, 2-chloro-1-(4- fluorobenzyl)-1H-benzo[d]imidazole, inhibited larval settlement and metamorphosis with low toxicity. These results may improve the understanding of the key functional group responsible for the anti-settlement activity of mizolastine. © 2009 Taylor & Francis.Citation
Zhou X, Xu Y, Jin C, Qian P-Y (2009) Reversible anti-settlement activity against Amphibalanus (= Balanus ) amphitrite, Bugula neritina , and Hydroides elegans by a nontoxic pharmaceutical compound, mizolastine . Biofouling 25: 739–747. Available: http://dx.doi.org/10.1080/08927010903154724.Sponsors
This study was supported by a grant from the Chinese Ocean Mineral Resources Research and Development Association (COMAR06/07.SC02), and the CAS/SAFEA International Partnership Program for Creative Research Teams as well as a research fund from KAUST International Partnership Program (KAUST005-CML.07/08) to Qian P.-Y.Publisher
Informa UK LimitedJournal
BiofoulingPubMed ID
20183132ae974a485f413a2113503eed53cd6c53
10.1080/08927010903154724
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