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    Regression calibration with more surrogates than mismeasured variables

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    Type
    Article
    Authors
    Kipnis, Victor
    Midthune, Douglas
    Freedman, Laurence S.
    Carroll, Raymond J.
    KAUST Grant Number
    KUS-CI-016-04
    Date
    2012-06-29
    Online Publication Date
    2012-06-29
    Print Publication Date
    2012-10-15
    Permanent link to this record
    http://hdl.handle.net/10754/599485
    
    Metadata
    Show full item record
    Abstract
    In a recent paper (Weller EA, Milton DK, Eisen EA, Spiegelman D. Regression calibration for logistic regression with multiple surrogates for one exposure. Journal of Statistical Planning and Inference 2007; 137: 449-461), the authors discussed fitting logistic regression models when a scalar main explanatory variable is measured with error by several surrogates, that is, a situation with more surrogates than variables measured with error. They compared two methods of adjusting for measurement error using a regression calibration approximate model as if it were exact. One is the standard regression calibration approach consisting of substituting an estimated conditional expectation of the true covariate given observed data in the logistic regression. The other is a novel two-stage approach when the logistic regression is fitted to multiple surrogates, and then a linear combination of estimated slopes is formed as the estimate of interest. Applying estimated asymptotic variances for both methods in a single data set with some sensitivity analysis, the authors asserted superiority of their two-stage approach. We investigate this claim in some detail. A troubling aspect of the proposed two-stage method is that, unlike standard regression calibration and a natural form of maximum likelihood, the resulting estimates are not invariant to reparameterization of nuisance parameters in the model. We show, however, that, under the regression calibration approximation, the two-stage method is asymptotically equivalent to a maximum likelihood formulation, and is therefore in theory superior to standard regression calibration. However, our extensive finite-sample simulations in the practically important parameter space where the regression calibration model provides a good approximation failed to uncover such superiority of the two-stage method. We also discuss extensions to different data structures.
    Citation
    Kipnis V, Midthune D, Freedman LS, Carroll RJ (2012) Regression calibration with more surrogates than mismeasured variables. Statistics in Medicine 31: 2713–2732. Available: http://dx.doi.org/10.1002/sim.5435.
    Sponsors
    We thank Dr. Weller for providing us with the data used in their original analysis. Carroll's research was supported by a grant from the National Cancer Institute (CA57030) and by Award Number KUS-CI-016-04, made by King Abdullah University of Science and Technology (KAUST).
    Publisher
    Wiley
    Journal
    Statistics in Medicine
    DOI
    10.1002/sim.5435
    PubMed ID
    22744878
    PubMed Central ID
    PMC3640838
    ae974a485f413a2113503eed53cd6c53
    10.1002/sim.5435
    Scopus Count
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