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dc.contributor.authorSo, Hongyun
dc.contributor.authorSeo, Young Ho
dc.contributor.authorPisano, Albert P.
dc.date.accessioned2016-02-28T05:51:56Z
dc.date.available2016-02-28T05:51:56Z
dc.date.issued2014-07
dc.identifier.citationSo H, Seo YH, Pisano AP (2014) Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane. Biomicrofluidics 8: 044119. Available: http://dx.doi.org/10.1063/1.4893912.
dc.identifier.issn1932-1058
dc.identifier.pmid25379104
dc.identifier.doi10.1063/1.4893912
dc.identifier.urihttp://hdl.handle.net/10754/599481
dc.description.abstractWe report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.
dc.description.sponsorshipThis work was supported by the KAUST Global Collaborative Research grant under the Academic Excellence Alliance program. The authors also thank the UC Berkeley Marvell Nanolab and Biomolecular Nanotechnology Center where all devices were fabricated.
dc.publisherAIP Publishing
dc.titleRefillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane
dc.typeArticle
dc.identifier.journalBiomicrofluidics
dc.identifier.pmcidPMC4189303
dc.contributor.institutionDepartment of Mechanical Engineering, University of California , Berkeley, California 94720, USA.
dc.contributor.institutionDepartment of Mechanical and Mechatronics Engineering, Kangwon National University , Chuncheon, Gangwon-do 200-701, South Korea.
kaust.grant.programAcademic Excellence Alliance (AEA)


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