Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane

Type
Article

Authors
So, Hongyun
Seo, Young Ho
Pisano, Albert P.

Date
2014-07

Abstract
We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.

Citation
So H, Seo YH, Pisano AP (2014) Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane. Biomicrofluidics 8: 044119. Available: http://dx.doi.org/10.1063/1.4893912.

Acknowledgements
This work was supported by the KAUST Global Collaborative Research grant under the Academic Excellence Alliance program. The authors also thank the UC Berkeley Marvell Nanolab and Biomolecular Nanotechnology Center where all devices were fabricated.

Publisher
AIP Publishing

Journal
Biomicrofluidics

DOI
10.1063/1.4893912

PubMed ID
25379104

PubMed Central ID
PMC4189303

Permanent link to this record