Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane
Type
ArticleDate
2014-07Permanent link to this record
http://hdl.handle.net/10754/599481
Metadata
Show full item recordAbstract
We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.Citation
So H, Seo YH, Pisano AP (2014) Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane. Biomicrofluidics 8: 044119. Available: http://dx.doi.org/10.1063/1.4893912.Sponsors
This work was supported by the KAUST Global Collaborative Research grant under the Academic Excellence Alliance program. The authors also thank the UC Berkeley Marvell Nanolab and Biomolecular Nanotechnology Center where all devices were fabricated.Publisher
AIP PublishingJournal
BiomicrofluidicsPubMed ID
25379104PubMed Central ID
PMC4189303ae974a485f413a2113503eed53cd6c53
10.1063/1.4893912
Scopus Count
Collections
Publications Acknowledging KAUST SupportRelated articles
- A magnetically controlled MEMS device for drug delivery: design, fabrication, and testing.
- Authors: Pirmoradi FN, Jackson JK, Burt HM, Chiao M
- Issue date: 2011 Sep 21
- Design and fabrication of a magnetically actuated non-invasive reusable drug delivery device.
- Authors: Dsa J, Goswami M, Singh BR, Bhatt N, Sharma P, Chauhan MK
- Issue date: 2018 Jul
- Performance Evaluation of a Magnetically Actuated Capsule Microrobotic System for Medical Applications.
- Authors: Fu Q, Zhang S, Guo S, Guo J
- Issue date: 2018 Dec 4
- Implantable small device enabled with magnetic actuation for on-demand and pulsatile drug delivery.
- Authors: Lee SH, Kim BH, Park CG, Lee C, Lim BY, Choy YB
- Issue date: 2018 Sep 28
- On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device.
- Authors: Pirmoradi FN, Jackson JK, Burt HM, Chiao M
- Issue date: 2011 Aug 21