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dc.contributor.authorMcDougal, Nolan T.
dc.contributor.authorStreuff, Jan
dc.contributor.authorMukherjee, Herschel
dc.contributor.authorVirgil, Scott C.
dc.contributor.authorStoltz, Brian M.
dc.date.accessioned2016-02-28T05:51:16Z
dc.date.available2016-02-28T05:51:16Z
dc.date.issued2010-10
dc.identifier.citationMcDougal NT, Streuff J, Mukherjee H, Virgil SC, Stoltz BM (2010) Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides. Tetrahedron Letters 51: 5550–5554. Available: http://dx.doi.org/10.1016/j.tetlet.2010.08.039.
dc.identifier.issn0040-4039
dc.identifier.pmid21076623
dc.identifier.doi10.1016/j.tetlet.2010.08.039
dc.identifier.urihttp://hdl.handle.net/10754/599445
dc.description.abstractHerein an efficient and direct copper-catalyzed coupling of oxazoline-containing aryl bromides with electron-deficient secondary phosphine oxides is reported. The resulting tertiary phosphine oxides can be reduced to prepare a range of PHOX ligands. The presented strategy is a useful alternative to known methods for constructing PHOX derivatives.
dc.description.sponsorshipThis publication is based on the work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Additionally, the authors wish to thank NIH-NIGMS (R01 GM 080269-01), the German Academic Exchange Service (DAAD, postdoctoral fellowship to J.S.), Abbott Laboratories, Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support.
dc.publisherElsevier BV
dc.titleRapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides
dc.typeArticle
dc.identifier.journalTetrahedron Letters
dc.identifier.pmcidPMC2976555
dc.contributor.institutionThe Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
kaust.grant.numberKUS-11-006-02


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