Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides
Type
ArticleKAUST Grant Number
KUS-11-006-02Date
2010-10Permanent link to this record
http://hdl.handle.net/10754/599445
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Herein an efficient and direct copper-catalyzed coupling of oxazoline-containing aryl bromides with electron-deficient secondary phosphine oxides is reported. The resulting tertiary phosphine oxides can be reduced to prepare a range of PHOX ligands. The presented strategy is a useful alternative to known methods for constructing PHOX derivatives.Citation
McDougal NT, Streuff J, Mukherjee H, Virgil SC, Stoltz BM (2010) Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides. Tetrahedron Letters 51: 5550–5554. Available: http://dx.doi.org/10.1016/j.tetlet.2010.08.039.Sponsors
This publication is based on the work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Additionally, the authors wish to thank NIH-NIGMS (R01 GM 080269-01), the German Academic Exchange Service (DAAD, postdoctoral fellowship to J.S.), Abbott Laboratories, Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support.Publisher
Elsevier BVJournal
Tetrahedron LettersPubMed ID
21076623PubMed Central ID
PMC2976555ae974a485f413a2113503eed53cd6c53
10.1016/j.tetlet.2010.08.039
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