Preparation and Characterization of Amphiphilic Triblock Terpolymer-Based Nanofibers as Antifouling Biomaterials
Online Publication Date2012-04-15
Print Publication Date2012-05-14
Permanent link to this recordhttp://hdl.handle.net/10754/599389
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AbstractAntifouling surfaces are critical for the good performance of functional materials in various applications including water filtration, medical implants, and biosensors. In this study, we synthesized amphiphilic triblock terpolymers (tri-BCPs, coded as KB) and fabricated amphiphilic nanofibers by electrospinning of solutions prepared by mixing the KB with poly(lactic acid) (PLA) polymer. The resulting fibers with amphiphilic polymer groups exhibited superior antifouling performance to the fibers without such groups. The adsorption of bovine serum albumin (BSA) on the amphiphilic fibers was about 10-fold less than that on the control surfaces from PLA and PET fibers. With the increase of the KB content in the amphiphilic fibers, the resistance to adsorption of BSA was increased. BSA was released more easily from the surface of the amphiphilic fibers than from the surface of hydrophobic PLA or PET fibers. We have also investigated the structural conformation of KB in fibers before and after annealing by contact angle measurements, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and coarse-grained molecular dynamics (CGMD) simulation to probe the effect of amphiphilic chain conformation on antifouling. The results reveal that the amphiphilic KB was evenly distributed within as-spun hybrid fibers, while migrated toward the core from the fiber surface during thermal treatment, leading to the reduction in antifouling. This suggests that the antifouling effect of the amphiphilic fibers is greatly influenced by the arrangement of amphiphilic groups in the fibers. © 2012 American Chemical Society.
CitationCho Y, Cho D, Park JH, Frey MW, Ober CK, et al. (2012) Preparation and Characterization of Amphiphilic Triblock Terpolymer-Based Nanofibers as Antifouling Biomaterials. Biomacromolecules 13: 1606–1614. Available: http://dx.doi.org/10.1021/bm300327w.
SponsorsThe authors are grateful for the financial support from NSF CBET-0852900 and the National Textile Center. This work was partially supported by the Office of Naval Research (ONR) through Award #N00014-02-1-0170, as well as through the KAUST CU Center for Energy and Sustainability.
PublisherAmerican Chemical Society (ACS)
CollectionsPublications Acknowledging KAUST Support
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