Practical and General Palladium-Catalyzed Synthesis of Ketones from Internal Olefins
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ArticleDate
2013-01-16Online Publication Date
2013-01-16Print Publication Date
2013-03-04Permanent link to this record
http://hdl.handle.net/10754/599374
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Make it simple! A convenient and general palladium-catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed-oil derivatives and a bioactive natural product (see scheme) are described, as well as intriguing mechanistic features.Citation
Morandi B, Wickens ZK, Grubbs RH (2013) Practical and General Palladium-Catalyzed Synthesis of Ketones from Internal Olefins. Angew Chem 125: 3016–3020. Available: http://dx.doi.org/10.1002/ange.201209541.Sponsors
We thank Scott Virgil and the Caltech Center for Catalysis for technical assistance. We gratefully acknowledge financial support from King Abdullah University of Science and Technology Center in Development, King Fahd University of Petroleum and Minerals, the NSF, and the Swiss National Science Foundation for a fellowship to B.M.Publisher
WileyJournal
Angewandte Chemieae974a485f413a2113503eed53cd6c53
10.1002/ange.201209541