Possible role of differential growth in airway wall remodeling in asthma
KAUST Grant NumberKUK-C1-013-04
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AbstractPossible role of differential growth in airway wall remodeling in asthma. J Appl Physiol 110: 1003-1012, 2011. First published January 20, 2011; doi:10.1152/japplphysiol.00991.2010.- Airway remodeling in patients with chronic asthma is characterized by a thickening of the airway walls. It has been demonstrated in previous theoretical models that this change in thickness can have an important mechanical effect on the properties of the wall, in particular on the phenomenon of mucosal folding induced by smooth muscle contraction. In this paper, we present a model for mucosal folding of the airway in the context of growth. The airway is modeled as a bilayered cylindrical tube, with both geometric and material nonlinearities accounted for via the theory of finite elasticity. Growth is incorporated into the model through the theory of morphoelasticity. We explore a range of growth possibilities, allowing for anisotropic growth as well as different growth rates in each layer. Such nonuniform growth, referred to as differential growth, can change the properties of the material beyond geometrical changes through the generation of residual stresses. We demonstrate that differential growth can have a dramatic impact on mucosal folding, in particular on the critical pressure needed to induce folding, the buckling pattern, as well as airway narrowing. We conclude that growth may be an important component in airway remodeling. Copyright © 2011 the American Physiological Society.
CitationMoulton DE, Goriely A (2011) Possible role of differential growth in airway wall remodeling in asthma. Journal of Applied Physiology 110: 1003–1012. Available: http://dx.doi.org/10.1152/japplphysiol.00991.2010.
SponsorsThis publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST), and based in part upon work supported by the National Science Foundation under grant DMS-0907773 (to A. Goriely). A. Goriely is a Wolfson/Royal Society Merit Award holder.
PublisherAmerican Physiological Society
JournalJournal of Applied Physiology
CollectionsPublications Acknowledging KAUST Support
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