Osmotic actuation for microfluidic components in point-of-care applications
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AbstractWe present a novel design of micropumps and valves driven by osmotic force for point-of-care applications. Although there have been significant progresses in microfluidic components and control devices such as fluidic diodes, switches, resonators and digital-to-analog converters, the ultimate power source still depends on bulky off-chip components, which are expensive and cannot be easily miniaturized. For point-of-care applications, it is critical to integrate all the components in a compact size at low cost. In this work, we report two key active components actuated by osmotic mechanism for total integrated microfluidic system. For the proof of concept, we have demonstrated valve actuation, which can maintain stable ON/OFF switching operations under 125 kPa back pressure. We have also implemented an osmotic pump, which can pump a high flow rate over 30 μL/min for longer than 30 minutes. The experimental data demonstrates the possibility and potential of applying osmotic actuation in point-of-care disposable microfluidics. © 2013 IEEE.
CitationChen Y-C, Ingram P, Lou X, Yoon E (2013) Osmotic actuation for microfluidic components in point-of-care applications. 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). Available: http://dx.doi.org/10.1109/MEMSYS.2013.6474448.
SponsorsThis work was supported in part by the Thermo Fisher Scientific Screening Technology Grant under the Center for Chemical Genomics at the Life Sciences Institute at the University of Michigan, and in part by Academic Excellence Alliance Award from KAUST.