Nonlinear electro-mechanobiological behavior of cell membrane during electroporation
Type
ArticleKAUST Grant Number
SA-C0040/UK-C0016Date
2012-07-30Online Publication Date
2012-07-30Print Publication Date
2012-07-30Permanent link to this record
http://hdl.handle.net/10754/598990
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Show full item recordAbstract
A nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. © 2012 American Institute of Physics.Citation
Deng P, Lee Y-K, Lin R, Zhang T-Y (2012) Nonlinear electro-mechanobiological behavior of cell membrane during electroporation. Applied Physics Letters 101: 053702. Available: http://dx.doi.org/10.1063/1.4739940.Sponsors
This research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from the King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016).Publisher
AIP PublishingJournal
Applied Physics Lettersae974a485f413a2113503eed53cd6c53
10.1063/1.4739940