Nonlinear electro-mechanobiological behavior of cell membrane during electroporation
KAUST Grant NumberSA-C0040/UK-C0016
Online Publication Date2012-07-30
Print Publication Date2012-07-30
Permanent link to this recordhttp://hdl.handle.net/10754/598990
MetadataShow full item record
AbstractA nonlinear electroporation (EP) model is proposed to study the electro-mechanobiological behavior of cell membrane during EP, by taking the nonlinear large deformation of the membrane into account. The proposed model predicts the critical transmembrane potential and the activation energy for EP, the equilibrium pore size, and the resealing process of the pore. Single-cell EP experiments using a micro EP chip were conducted on chicken red blood cells at different temperatures to determine the activation energy and the critical transmembrane potential for EP. The experimental results are in good agreement with the theoretical predictions. © 2012 American Institute of Physics.
CitationDeng P, Lee Y-K, Lin R, Zhang T-Y (2012) Nonlinear electro-mechanobiological behavior of cell membrane during electroporation. Applied Physics Letters 101: 053702. Available: http://dx.doi.org/10.1063/1.4739940.
SponsorsThis research was partially supported by a Hong Kong RGC grant (No. 615907) and by an award from the King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-C0016).
JournalApplied Physics Letters