KAUST Grant NumberKUK-C1-013-04
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AbstractRecent advances in engineered muscle tissue attached to a synthetic substrate motivate the development of appropriate constitutive and numerical models. Applications of active materials can be expanded by using robust, non-mammalian muscle cells, such as those of Manduca sexta. In this study, we propose a model to assist in the analysis of biohybrid constructs by generalizing a recently proposed constitutive law for Manduca muscle tissue. The continuum model accounts (i) for the stimulation of muscle fibers by introducing multiple stress-free reference configurations for the active and passive states and (ii) for the hysteretic response by specifying a pseudo-elastic energy function. A simple example representing uniaxial loading-unloading is used to validate and verify the characteristics of the model. Then, based on experimental data of muscular thin films, a more complex case shows the qualitative potential of Manduca muscle tissue in active biohybrid constructs. © 2013 Elsevier Ltd. All rights reserved.
CitationPaetsch C, Dorfmann A (2013) Non-linear modeling of active biohybrid materials. International Journal of Non-Linear Mechanics 56: 105–114. Available: http://dx.doi.org/10.1016/j.ijnonlinmec.2013.03.005.
SponsorsThis publication was based on work supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). The work of C.P. was supported in part by the National Science Foundation IGERT Grant DGE-1144591.