Modeling the Mechanical Response of In Vivo Human Skin Under a Rich Set of Deformations
KAUST Grant NumberKUK-C1-013-04
Permanent link to this recordhttp://hdl.handle.net/10754/598863
MetadataShow full item record
AbstractDetermining the mechanical properties of an individual's skin is important in the fields of pathology, biomedical device design, and plastic surgery. To address this need, we present a finite element model that simulates the skin of the anterior forearm and posterior upper arm under a rich set of three-dimensional deformations. We investigated the suitability of the Ogden and Tong and Fung strain energy functions along with a quasi-linear viscoelastic law. Using non-linear optimization techniques, we found material parameters and in vivo pre-stresses for different volunteers. The model simulated the experiments with errors-of-fit ranging from 13.7 to 21.5%. Pre-stresses ranging from 28 to 92 kPa were estimated. We show that using only in-plane experimental data in the parameter optimization results in a poor prediction of the out-of-plane response. The identifiability of the model parameters, which are evaluated using different determinability criteria, improves by increasing the number of deformation orientations in the experiments. © 2011 Biomedical Engineering Society.
CitationFlynn C, Taberner A, Nielsen P (2011) Modeling the Mechanical Response of In Vivo Human Skin Under a Rich Set of Deformations. Ann Biomed Eng 39: 1935–1946. Available: http://dx.doi.org/10.1007/s10439-011-0292-7.
SponsorsThis work was supported by the New Zealand Foundation for Research, Science, and Technology, through grants NERF 139400 and NERF 9077/3608892. This publication is also based on work supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
JournalAnnals of Biomedical Engineering
CollectionsPublications Acknowledging KAUST Support
- Estimating material parameters of human skin in vivo.
- Authors: Kvistedal YA, Nielsen PM
- Issue date: 2009 Feb
- Mechanical characterisation of in vivo human skin using a 3D force-sensitive micro-robot and finite element analysis.
- Authors: Flynn C, Taberner A, Nielsen P
- Issue date: 2011 Feb
- Quantifying the mechanical properties of human skin to optimise future microneedle device design.
- Authors: Groves RB, Coulman SA, Birchall JC, Evans SL
- Issue date: 2012
- Measurement and characterization of soft tissue behavior with surface deformation and force response under large deformations.
- Authors: Ahn B, Kim J
- Issue date: 2010 Apr
- Dual-parameter optimisation of the elastic properties of skin.
- Authors: Delalleau A, Josse G, Lagarde JM
- Issue date: 2012