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dc.contributor.authorZiebert, F.
dc.contributor.authorSwaminathan, S.
dc.contributor.authorAranson, I. S.
dc.date.accessioned2016-02-25T13:42:23Z
dc.date.available2016-02-25T13:42:23Z
dc.date.issued2011-10-19
dc.identifier.citationZiebert F, Swaminathan S, Aranson IS (2011) Model for self-polarization and motility of keratocyte fragments. Journal of The Royal Society Interface 9: 1084–1092. Available: http://dx.doi.org/10.1098/rsif.2011.0433.
dc.identifier.issn1742-5689
dc.identifier.issn1742-5662
dc.identifier.pmid22012972
dc.identifier.doi10.1098/rsif.2011.0433
dc.identifier.urihttp://hdl.handle.net/10754/598849
dc.description.abstractComputational modelling of cell motility on substrates is a formidable challenge; regulatory pathways are intertwined and forces that influence cell motion are not fully quantified. Additional challenges arise from the need to describe a moving deformable cell boundary. Here, we present a simple mathematical model coupling cell shape dynamics, treated by the phase-field approach, to a vector field describing the mean orientation (polarization) of the actin filament network. The model successfully reproduces the primary phenomenology of cell motility: discontinuous onset of motion, diversity of cell shapes and shape oscillations. The results are in qualitative agreement with recent experiments on motility of keratocyte cells and cell fragments. The asymmetry of the shapes is captured to a large extent in this simple model, which may prove useful for the interpretation of experiments.
dc.description.sponsorshipWe thank J. Oliver, P. Sens, E. Raphael, J. Prost, J.-F. Joanny, F. Julicher and K. Kruse for stimulating discussions. We also would like to thank one of the referees to point out the connection to nematic droplets. F.Z. thanks the DFG for partial funding via IRTG 1642 Soft Matter Science. S.S. acknowledges support from KAUST, the University of Oxford and the DDR&E and AFOSR under Award No. FA9550-10-1-0167. I.S.A. thanks the ESPCI for hospitality and the CNRS for support during his stay. The work of I.S.A. was supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering, under Contract DE-AC02-06CH11357.
dc.publisherThe Royal Society
dc.subjectActin self-assembly
dc.subjectCell motility
dc.subjectNonlinear physics
dc.subject.meshModels, Biological
dc.titleModel for self-polarization and motility of keratocyte fragments
dc.typeArticle
dc.identifier.journalJournal of The Royal Society Interface
dc.identifier.pmcidPMC3306635
dc.contributor.institutionUniversitat Freiburg im Breisgau, Freiburg im Breisgau, Germany
dc.contributor.institutionInstitut Charles Sadron, Strasbourg, France
dc.contributor.institutionGulliver, Paris, France
dc.contributor.institutionNorthwestern University, Evanston, United States
dc.contributor.institutionArgonne National Laboratory, Argonne, United States


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