Methods for Estimation of Radiation Risk in Epidemiological Studies Accounting for Classical and Berkson Errors in Doses
Carroll, Raymond J
KAUST Grant NumberKUSCI-016-04
Permanent link to this recordhttp://hdl.handle.net/10754/598819
MetadataShow full item record
AbstractWith a binary response Y, the dose-response model under consideration is logistic in flavor with pr(Y=1 | D) = R (1+R)(-1), R = λ(0) + EAR D, where λ(0) is the baseline incidence rate and EAR is the excess absolute risk per gray. The calculated thyroid dose of a person i is expressed as Dimes=fiQi(mes)/Mi(mes). Here, Qi(mes) is the measured content of radioiodine in the thyroid gland of person i at time t(mes), Mi(mes) is the estimate of the thyroid mass, and f(i) is the normalizing multiplier. The Q(i) and M(i) are measured with multiplicative errors Vi(Q) and ViM, so that Qi(mes)=Qi(tr)Vi(Q) (this is classical measurement error model) and Mi(tr)=Mi(mes)Vi(M) (this is Berkson measurement error model). Here, Qi(tr) is the true content of radioactivity in the thyroid gland, and Mi(tr) is the true value of the thyroid mass. The error in f(i) is much smaller than the errors in ( Qi(mes), Mi(mes)) and ignored in the analysis. By means of Parametric Full Maximum Likelihood and Regression Calibration (under the assumption that the data set of true doses has lognormal distribution), Nonparametric Full Maximum Likelihood, Nonparametric Regression Calibration, and by properly tuned SIMEX method we study the influence of measurement errors in thyroid dose on the estimates of λ(0) and EAR. The simulation study is presented based on a real sample from the epidemiological studies. The doses were reconstructed in the framework of the Ukrainian-American project on the investigation of Post-Chernobyl thyroid cancers in Ukraine, and the underlying subpolulation was artificially enlarged in order to increase the statistical power. The true risk parameters were given by the values to earlier epidemiological studies, and then the binary response was simulated according to the dose-response model.
CitationKukush A, Shklyar S, Masiuk S, Likhtarov I, Kovgan L, et al. (2011) Methods for Estimation of Radiation Risk in Epidemiological Studies Accounting for Classical and Berkson Errors in Doses. The International Journal of Biostatistics 7: 1–30. Available: http://dx.doi.org/10.2202/1557-4679.1281.
SponsorsThis work was supported by funds from the U.S. National Cancer Institute and the Radiation Protection Institute ATS of Ukraine. The authors also want to thank their colleges from the Institute of Endocrinology and Metabolism AMS of Ukraine and the Radiation Protection Institute ATS of Ukraine who contributed to the preparation of the results presented in the paper. Alexander Kukush is supported by the Swedish Institute grant SI-01424/2007. Carroll's research was supported by a grant from the National Cancer Institute (CA57030). This publication is based in part on work supported by Award Number KUSCI-016-04, made by King Abdullah University of Science and Technology (KAUST).
PublisherWalter de Gruyter GmbH
PubMed Central IDPMC3058406
CollectionsPublications Acknowledging KAUST Support
- Estimation of radiation risk in presence of classical additive and Berkson multiplicative errors in exposure doses.
- Authors: Masiuk SV, Shklyar SV, Kukush AG, Carroll RJ, Kovgan LN, Likhtarov IA
- Issue date: 2016 Jul
- Impact of uncertainties in exposure assessment on estimates of thyroid cancer risk among Ukrainian children and adolescents exposed from the Chernobyl accident.
- Authors: Little MP, Kukush AG, Masiuk SV, Shklyar S, Carroll RJ, Lubin JH, Kwon D, Brenner AV, Tronko MD, Mabuchi K, Bogdanova TI, Hatch M, Zablotska LB, Tereshchenko VP, Ostroumova E, Bouville AC, Drozdovitch V, Chepurny MI, Kovgan LN, Simon SL, Shpak VM, Likhtarev IA
- Issue date: 2014
- Questionnaire- and measurement-based individual thyroid doses in Ukraine resulting from the Chornobyl nuclear reactor accident.
- Authors: Likhtarev I, Bouville A, Kovgan L, Luckyanov N, Voillequé P, Chepurny M
- Issue date: 2006 Jul
- I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident.
- Authors: Brenner AV, Tronko MD, Hatch M, Bogdanova TI, Oliynik VA, Lubin JH, Zablotska LB, Tereschenko VP, McConnell RJ, Zamotaeva GA, O'Kane P, Bouville AC, Chaykovskaya LV, Greenebaum E, Paster IP, Shpak VM, Ron E
- Issue date: 2011 Jul
- Berkson errors in radiation dose assessments and their impact on radiation risk estimates.
- Authors: Masiuk SV, Shklyar SV, Kukush AG
- Issue date: 2013