Mathematical modelling of digit specification by a sonic hedgehog gradient
KAUST Grant NumberKUK-C1-013-04
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AbstractBackground: The three chick wing digits represent a classical example of a pattern specified by a morphogen gradient. Here we have investigated whether a mathematical model of a Shh gradient can describe the specification of the identities of the three chick wing digits and if it can be applied to limbs with more digits. Results: We have produced a mathematical model for specification of chick wing digit identities by a Shh gradient that can be extended to the four digits of the chick leg with Shh-producing cells forming a digit. This model cannot be extended to specify the five digits of the mouse limb. Conclusions: Our data suggest that the parameters of a classical-type morphogen gradient are sufficient to specify the identities of three different digits. However, to specify more digit identities, this core mechanism has to be coupled to alternative processes, one being that in the chick leg and mouse limb, Shh-producing cells give rise to digits; another that in the mouse limb, the cellular response to the Shh gradient adapts over time so that digit specification does not depend simply on Shh concentration. Developmental Dynamics 243:290-298, 2014. © 2013 Wiley Periodicals, Inc.
CitationWoolley TE, Baker RE, Tickle C, Maini PK, Towers M (2013) Mathematical modelling of digit specification by a sonic hedgehog gradient. Developmental Dynamics 243: 290–298. Available: http://dx.doi.org/10.1002/dvdy.24068.
SponsorsGrant sponsor: King Abdullah, University of Science and Technology (KAUST); Grant number: KUK-C1-013-04.
CollectionsPublications Acknowledging KAUST Support
- Integration of growth and specification in chick wing digit-patterning.
- Authors: Towers M, Mahood R, Yin Y, Tickle C
- Issue date: 2008 Apr 17
- Inhibition of Shh signalling in the chick wing gives insights into digit patterning and evolution.
- Authors: Pickering J, Towers M
- Issue date: 2016 Oct 1
- Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb.
- Authors: Scherz PJ, McGlinn E, Nissim S, Tabin CJ
- Issue date: 2007 Aug 15
- The Sonic hedgehog gradient in the developing limb.
- Authors: Tickle C, Barker H
- Issue date: 2013 Mar-Apr
- A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling.
- Authors: Drossopoulou G, Lewis KE, Sanz-Ezquerro JJ, Nikbakht N, McMahon AP, Hofmann C, Tickle C
- Issue date: 2000 Apr