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dc.contributor.authorProkopiou, Sotiris A.
dc.contributor.authorByrne, Helen M.
dc.contributor.authorJeffrey, Mike R.
dc.contributor.authorRobinson, Robert S.
dc.contributor.authorMann, George E.
dc.contributor.authorOwen, Markus R.
dc.date.accessioned2016-02-25T13:40:46Z
dc.date.available2016-02-25T13:40:46Z
dc.date.issued2013-12-13
dc.identifier.citationProkopiou SA, Byrne HM, Jeffrey MR, Robinson RS, Mann GE, et al. (2013) Mathematical analysis of a model for the growth of the bovine corpus luteum. Journal of Mathematical Biology 69: 1515–1546. Available: http://dx.doi.org/10.1007/s00285-013-0722-2.
dc.identifier.issn0303-6812
dc.identifier.issn1432-1416
dc.identifier.pmid24337679
dc.identifier.doi10.1007/s00285-013-0722-2
dc.identifier.urihttp://hdl.handle.net/10754/598765
dc.description.abstractThe corpus luteum (CL) is an ovarian tissue that grows in the wound space created by follicular rupture. It produces the progesterone needed in the uterus to maintain pregnancy. Rapid growth of the CL and progesterone transport to the uterus require angiogenesis, the creation of new blood vessels from pre-existing ones, a process which is regulated by proteins that include fibroblast growth factor 2 (FGF2). In this paper we develop a system of time-dependent ordinary differential equations to model CL growth. The dependent variables represent FGF2, endothelial cells (ECs), luteal cells, and stromal cells (like pericytes), by assuming that the CL volume is a continuum of the three cell types. We assume that if the CL volume exceeds that of the ovulated follicle, then growth is inhibited. This threshold volume partitions the system dynamics into two regimes, so that the model may be classified as a Filippov (piecewise smooth) system. We show that normal CL growth requires an appropriate balance between the growth rates of luteal and stromal cells. We investigate how angiogenesis influences CL growth by considering how the system dynamics depend on the dimensionless EC proliferation rate, {Mathematical expression}. We find that weak (low {Mathematical expression}) or strong (high {Mathematical expression}) angiogenesis leads to 'pathological' CL growth, since the loss of CL constituents compromises progesterone production or delivery. However, for intermediate values of {Mathematical expression}, normal CL growth is predicted. The implications of these results for cow fertility are also discussed. For example, inadequate angiogenesis has been linked to infertility in dairy cows. © 2013 Springer-Verlag Berlin Heidelberg.
dc.description.sponsorshipSAP acknowledges support from the Schools of Biosciences and Mathematical Sciences at the University of Nottingham in the form of a PhD studentship. MRJ's research is supported by EPSRC grant EP/J001317/1. This publication was based in part on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
dc.publisherSpringer Nature
dc.subjectAngiogenesis
dc.subjectCorpus luteum
dc.subjectPiecewise smooth systems
dc.subjectSliding bifurcations
dc.titleMathematical analysis of a model for the growth of the bovine corpus luteum
dc.typeArticle
dc.identifier.journalJournal of Mathematical Biology
dc.contributor.institutionUniversity of Nottingham, Nottingham, United Kingdom
dc.contributor.institutionUniversity of Oxford, Oxford, United Kingdom
dc.contributor.institutionUniversity of Bristol, Bristol, United Kingdom
kaust.grant.numberKUK-C1-013-04
dc.date.published-online2013-12-13
dc.date.published-print2014-12


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