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    iTRAQ-Based Proteomic Profiling of the Barnacle Balanus amphitrite in Response to the Antifouling Compound Meleagrin

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    Type
    Article
    Authors
    Han, Zhuang
    Sun, Jin
    Zhang, Yu
    He, Fei
    Xu, Ying
    Matsumura, Kiyotaka
    He, Li-Sheng
    Qiu, Jian-Wen cc
    Qi, Shu-Hua
    Qian, Pei-Yuan cc
    KAUST Grant Number
    SA-C0040
    UK-C0016
    Date
    2013-04-24
    Online Publication Date
    2013-04-24
    Print Publication Date
    2013-05-03
    Permanent link to this record
    http://hdl.handle.net/10754/598679
    
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    Abstract
    Marine biofouling refers to the unwanted accumulation of fouling organisms, such as barnacles, on artificial surfaces, resulting in severe consequences for marine industries. Meleagrin is a potential nontoxic antifoulant that is isolated from the fungus Penicillium sp.; however, its mechanistic effect mode of action on larval settlement remains unknown. Here, we applied iTRAQ coupled with 2D LC-MS/MS proteomic analysis to investigate the effect of meleagrin on the proteomic expression profile of cyprid development and aging in the barnacle Balanus amphitrite. Fifty proteins were differentially expressed in response to treatment with meleagrin, among which 26 proteins were associated with cyprid development/aging and 24 were specifically associated with the meleagrin treatment. The 66 proteins that were associated with aging only remained unaltered during exposure to meleagrin. Using KEGG analysis, those proteins were assigned to several groups, including metabolic pathways, ECM-receptor interactions, and the regulation of the actin cytoskeleton. Among the 24 proteins that were not related to the development/aging process, expression of the cyprid major protein (CMP), a vitellogenin-like protein, increased after the meleagrin treatment, which suggested that meleagrin might affect the endocrine system and prevent the larval molting cycle. With the exception of the chitin binding protein that mediates the molting process and ATPase-mediated energy processes, the majority of proteins with significant effects in previous studies in response to cyprid treatment with butenolide and polyether B remained unchanged in the present study, suggesting that meleagrin may exhibit a different mechanism. © 2013 American Chemical Society.
    Citation
    Han Z, Sun J, Zhang Y, He F, Xu Y, et al. (2013) iTRAQ-Based Proteomic Profiling of the Barnacle Balanus amphitrite in Response to the Antifouling Compound Meleagrin . Journal of Proteome Research 12: 2090–2100. Available: http://dx.doi.org/10.1021/pr301083e.
    Sponsors
    This work was supported by a grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, a joint research grant from the Research Grants Council of the HKSAR and the National Natural Science Foundation of China (N_HKUST602/09), and award (SA-C0040/UK-C0016) from King Abdullah University of Science and Technology to P.Y. Qian.
    Publisher
    American Chemical Society (ACS)
    Journal
    Journal of Proteome Research
    DOI
    10.1021/pr301083e
    PubMed ID
    23540395
    ae974a485f413a2113503eed53cd6c53
    10.1021/pr301083e
    Scopus Count
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