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    Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition

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    Type
    Article
    Authors
    Caroli, Antonia
    Simeoni, Silvia
    Lepore, Rosalba
    Tramontano, Anna
    Via, Allegra
    KAUST Grant Number
    KUK-I1-012-43
    Date
    2012-01
    Permanent link to this record
    http://hdl.handle.net/10754/598665
    
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    Abstract
    Schistosoma mansoni and Plasmodium falciparum are pathogen parasites that spend part of their lives in the blood stream of the human host and are therefore heavily exposed to fluxes of toxic reactive oxygen species (ROS). SmTGR, an essential enzyme of the S. mansoni ROS detoxification machinery, is known to be inhibited by Auranofin although the inhibition mechanism has not been completely clarified. Auranofin also kills P. falciparum, even if its molecular targets are unknown. Here, we used computational and docking techniques to investigate the molecular mechanism of interaction between SmTGR and Auranofin. Furthermore, we took advantage of the homology relationship and of docking studies to assess if PfTR, the SmTGR malaria parasite homologue, can be a putative target for Auranofin. Our findings support a recently hypothesized molecular mechanism of inhibition for SmTGR and suggest that PfTR is indeed a possible and attractive drug target in P. falciparum. © 2011 Elsevier Inc.
    Citation
    Caroli A, Simeoni S, Lepore R, Tramontano A, Via A (2012) Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition. Biochemical and Biophysical Research Communications 417: 576–581. Available: http://dx.doi.org/10.1016/j.bbrc.2011.12.009.
    Sponsors
    We thank the members of the Fondazione Roma Research Unit led by Prof. Maurizio Brunori for useful discussions and Prof. Arthur Lesk for critically reading the manuscript. This work was partially supported by Award number KUK-I1-012-43 made by King Abdullah University of Science and Technology (KAUST), FIRB Proteomica, Ministery of Health Grant Contract No. Onc_Ord 25/07, Fondazione Roma and the IIT SEED project.
    Publisher
    Elsevier BV
    Journal
    Biochemical and Biophysical Research Communications
    DOI
    10.1016/j.bbrc.2011.12.009
    PubMed ID
    22177949
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbrc.2011.12.009
    Scopus Count
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