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dc.contributor.authorZhang, L.
dc.contributor.authorMallick, B. K.
dc.date.accessioned2016-02-25T13:33:16Z
dc.date.available2016-02-25T13:33:16Z
dc.date.issued2013-07-18
dc.identifier.citationZhang L, Mallick BK (2013) Inferring gene networks from discrete expression data. Biostatistics 14: 708–722. Available: http://dx.doi.org/10.1093/biostatistics/kxt021.
dc.identifier.issn1465-4644
dc.identifier.issn1468-4357
dc.identifier.pmid23873894
dc.identifier.doi10.1093/biostatistics/kxt021
dc.identifier.urihttp://hdl.handle.net/10754/598620
dc.description.abstractThe modeling of gene networks from transcriptional expression data is an important tool in biomedical research to reveal signaling pathways and to identify treatment targets. Current gene network modeling is primarily based on the use of Gaussian graphical models applied to continuous data, which give a closedformmarginal likelihood. In this paper,we extend network modeling to discrete data, specifically data from serial analysis of gene expression, and RNA-sequencing experiments, both of which generate counts of mRNAtranscripts in cell samples.We propose a generalized linear model to fit the discrete gene expression data and assume that the log ratios of the mean expression levels follow a Gaussian distribution.We restrict the gene network structures to decomposable graphs and derive the graphs by selecting the covariance matrix of the Gaussian distribution with the hyper-inverse Wishart priors. Furthermore, we incorporate prior network models based on gene ontology information, which avails existing biological information on the genes of interest. We conduct simulation studies to examine the performance of our discrete graphical model and apply the method to two real datasets for gene network inference. © The Author 2013. Published by Oxford University Press. All rights reserved.
dc.description.sponsorshipThe research was supported by grants from the National Science Foundation DMS grant 0914951 and the KUS-CI-016-04 made by King Abdullah University of Science and Technology (KAUST).
dc.publisherOxford University Press (OUP)
dc.subjectDiscrete graphical model
dc.subjectGene expression network
dc.subjectGene ontology
dc.subjectRNA-Seq
dc.subjectSAGE
dc.titleInferring gene networks from discrete expression data
dc.typeArticle
dc.identifier.journalBiostatistics
dc.contributor.institutionTexas A and M University, College Station, United States
kaust.grant.numberKUS-CI-016-04
dc.date.published-online2013-07-18
dc.date.published-print2013-09


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