KAUST Grant NumberKUK-I1-012-43
Permanent link to this recordhttp://hdl.handle.net/10754/598519
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AbstractMolecular mimicry is one of the powerful stratagems that pathogens employ to colonise their hosts and take advantage of host cell functions to guarantee their replication and dissemination. In particular, several viruses have evolved the ability to interact with host cell components through protein short linear motifs (SLiMs) that mimic host SLiMs, thus facilitating their internalisation and the manipulation of a wide range of cellular networks. Here we present convincing evidence from the literature that motif mimicry also represents an effective, widespread hijacking strategy in prokaryotic and eukaryotic parasites. Further insights into host motif mimicry would be of great help in the elucidation of the molecular mechanisms behind host cell invasion and the development of anti-infective therapeutic strategies.
CitationVia A, Uyar B, Brun C, Zanzoni A (2015) How pathogens use linear motifs to perturb host cell networks. Trends in Biochemical Sciences 40: 36–48. Available: http://dx.doi.org/10.1016/j.tibs.2014.11.001.
SponsorsThe authors are grateful to David G. Biron (CNRS, France), Toby J. Gibson (EMBL, Germany), and Vincenzo Petrarca (Sapienza University, Italy) for critically reading the manuscript and providing fruitful suggestions. A.V. acknowledges the King Abdullah University of Science and Technology (KAUST) Award No. KUK-I1-012-43 for funding support. C.B. and A.Z. received financial support from the French 'Plan Cancer 2009-2013' (Systems Biology call, A12171AS).
JournalTrends in Biochemical Sciences
CollectionsPublications Acknowledging KAUST Support
- Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions.
- Authors: Chemes LB, de Prat-Gay G, Sánchez IE
- Issue date: 2015 Jun
- Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks.
- Authors: Garamszegi S, Franzosa EA, Xia Y
- Issue date: 2013
- Fuzziness endows viral motif-mimicry.
- Authors: Duro N, Miskei M, Fuxreiter M
- Issue date: 2015 Oct
- The evolutionary conundrum of pathogen mimicry.
- Authors: Elde NC, Malik HS
- Issue date: 2009 Nov
- Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey.
- Authors: Ruhanen H, Hurley D, Ghosh A, O'Brien KT, Johnston CR, Shields DC
- Issue date: 2014