Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization

Type
Article

Authors
Fetsch, Corinna
Luxenhofer, Robert

KAUST Grant Number
KUK-F1-029-32

Online Publication Date
2012-06-05

Print Publication Date
2012-10-15

Date
2012-06-05

Abstract
Advanced macromolecular engineering requires excellent control over the polymerization reaction. Living polymerization methods are notoriously sensitive to impurities, which makes a practical realization of such control very challenging. Reversible-deactivation radical polymerization methods are typically more robust, but have other limitations. Here, we demonstrate by repeated (ge;10 times) chain extension the extraordinary robustness of the living nucleophilic ring-opening polymerization of N-substituted glycine N-carboxyanhydrides, which yields polypeptoids. We observe essentially quantitative end-group fidelity under experimental conditions that are comparatively easily managed. This is employed to synthesize a pentablock quinquiespolymer with high definition. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation
Fetsch C, Luxenhofer R (2012) Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization. Macromolecular Rapid Communications 33: 1708–1713. Available: http://dx.doi.org/10.1002/marc.201200189.

Acknowledgements
This publication is based on work supported by Award No. KUK-F1-029-32, made by King Abdullah University of Science and Technology (KAUST).

Publisher
Wiley

Journal
Macromolecular Rapid Communications

DOI
10.1002/marc.201200189

PubMed ID
22674859

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