Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure
Type
ArticleAuthors
Suteewong, TeerapornSai, Hiroaki
Cohen, Roy
Wang, Suntao
Bradbury, Michelle
Baird, Barbara
Gruner, Sol M.
Wiesner, Ulrich
Date
2011-01-19Permanent link to this record
http://hdl.handle.net/10754/598498
Metadata
Show full item recordAbstract
Mesoporous silica with cubic symmetry has attracted interest from researchers for some time. Here, we present the room temperature synthesis of mesoporous silica nanoparticles possessing cubic Pm3n symmetry with very high molar ratios (>50%) of 3-aminopropyl triethoxysilane. The synthesis is robust allowing, for example, co-condensation of organic dyes without loss of structure. By means of pore expander molecules, the pore size can be enlarged from 2.7 to 5 nm, while particle size decreases. Adding pore expander and co-condensing fluorescent dyes in the same synthesis reduces average particle size further down to 100 nm. After PEGylation, such fluorescent aminated mesoporous silica nanoparticles are spontaneously taken up by cells as demonstrated by fluorescence microscopy.Citation
Suteewong T, Sai H, Cohen R, Wang S, Bradbury M, et al. (2011) Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure. Journal of the American Chemical Society 133: 172–175. Available: http://dx.doi.org/10.1021/ja1061664.Sponsors
This work was supported by the Cornell Center for Materials Research (CCMR) with funding from a PREM program at Norfolk State University through the National Science Foundation (NSF) grant (DMR-0611430), by the Department of Energy grant DE-FG02-97ER62443 and by the National Institute of Dental and Craniofacial Research (R21DE018335). We thank the Cornell Universiy KAUST Center for Research and Education for financial support. This work was further supported by the U.S. Department of Homeland Security under Cooperative Agreement Number "2009-ST-108-LR0004". The authors thank CCMR for facility support. This work is based upon research conducted at the Cornell High Energy Synchrotron Source (CHESS), which is supported by the NSF and the National Institutes of Health/National Institute of General Medical Sciences under NSF award DMR-0225180. T.S. is grateful for a Thai Government Scholarship tinder the Ministry of Science and Technology.Publisher
American Chemical Society (ACS)PubMed ID
21158438PubMed Central ID
PMC3084371ae974a485f413a2113503eed53cd6c53
10.1021/ja1061664
Scopus Count
Collections
Publications Acknowledging KAUST SupportRelated articles
- One-Pot Synthesis of Aminated Bimodal Mesoporous Silica Nanoparticles as Silver-Embedded Antibacterial Nanocarriers and CO(2) Capture Sorbents.
- Authors: Li Y, Tiwari AK, Ng JS, Seah GL, Lim HK, Suteewong T, Tay CY, Lam YM, Tan KW
- Issue date: 2022 Nov 23
- Monodispersed mesoporous silica nanoparticles with very large pores for enhanced adsorption and release of DNA.
- Authors: Gao F, Botella P, Corma A, Blesa J, Dong L
- Issue date: 2009 Feb 12
- Formation pathways of mesoporous silica nanoparticles with dodecagonal tiling.
- Authors: Sun Y, Ma K, Kao T, Spoth KA, Sai H, Zhang D, Kourkoutis LF, Elser V, Wiesner U
- Issue date: 2017 Aug 15
- Carbohydrate coated fluorescent mesoporous silica particles for bacterial imaging.
- Authors: Kirla H, Hughes L, Henry DJ
- Issue date: 2020 Apr
- Preparation and Controllability of Mesoporous Silica Nanoparticles.
- Authors: Yamamoto E, Kuroda K
- Issue date: 2018