Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies
El-Sagheer, Afaf H.
Permanent link to this recordhttp://hdl.handle.net/10754/598387
MetadataShow full item record
AbstractWe have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption. © 2010 American Chemical Society.
CitationBörjesson K, Wiberg J, El-Sagheer AH, Ljungdahl T, Mårtensson J, et al. (2010) Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies. ACS Nano 4: 5037–5046. Available: http://dx.doi.org/10.1021/nn100667b.
SponsorsThis research is founded by King Abdullah University of Science and Technology, The Swedish Research Council (VR), The Swedish Energy Agency, and Knut and Alice Wallenbergs Foundation.
PublisherAmerican Chemical Society (ACS)
CollectionsPublications Acknowledging KAUST Support
- Membrane-anchored DNA assembly for energy and electron transfer.
- Authors: Börjesson K, Tumpane J, Ljungdahl T, Wilhelmsson LM, Nordén B, Brown T, Mårtensson J, Albinsson B
- Issue date: 2009 Mar 4
- Molecular energy and electron transfer assemblies made of self-organized lipid-porphyrin bilayer vesicles.
- Authors: Komatsu T, Moritake M, Tsuchida E
- Issue date: 2003 Oct 6
- Reversible hybridization of DNA anchored to a lipid membrane via porphyrin.
- Authors: Woller JG, Börjesson K, Svedhem S, Albinsson B
- Issue date: 2012 Jan 31
- Self-organized lipid-porphyrin bilayer membranes in vesicular form: nanostructure, photophysical properties, and dioxygen coordination.
- Authors: Komatsu T, Moritake M, Nakagawa A, Tsuchida E
- Issue date: 2002 Dec 2
- DNA as supramolecular scaffold for porphyrin arrays on the nanometer scale.
- Authors: Fendt LA, Bouamaied I, Thöni S, Amiot N, Stulz E
- Issue date: 2007 Dec 12