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Acknowledgements
This research supported in part by NSF awards CNS-0551685, CCF-0833199, CCF-0830753, IIS-0916053, IIS-0917266, EFRI-1240483, RI-1217991, by NIH NCI R25 CA090301-11, by DOE awards DE-AC02-06CH11357, B575363, by Samsung, by Award KUS-C1-016-04, made by King Abdullah University of Science and Technology (KAUST). This research used resources of the National Energy Research Scientific Computing Center, which is supported by the O ce of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.