Evaluation of template-based models in CASP8 with standard measures
Type
ArticleAuthors
Cozzetto, DomenicoKryshtafovych, Andriy

Fidelis, Krzysztof

Moult, John
Rost, Burkhard
Tramontano, Anna
KAUST Grant Number
KUK-11-012-43Date
2009-08-05Online Publication Date
2009-08-05Print Publication Date
2009Permanent link to this record
http://hdl.handle.net/10754/598255
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Show full item recordAbstract
The strategy for evaluating template-based models submitted to CASP has continuously evolved from CASP1 to CASP5, leading to a standard procedure that has been used in all subsequent editions. The established approach includes methods for calculating the quality of each individual model, for assigning scores based on the distribution of the results for each target and for computing the statistical significance of the differences in scores between prediction methods. These data are made available to the assessor of the template-based modeling category, who uses them as a starting point for further evaluations and analyses. This article describes the detailed workflow of the procedure, provides justifications for a number of choices that are customarily made for CASP data evaluation, and reports the results of the analysis of template-based predictions at CASP8.Citation
Cozzetto D, Kryshtafovych A, Fidelis K, Moult J, Rost B, et al. (2009) Evaluation of template-based models in CASP8 with standard measures. Proteins: Structure, Function, and Bioinformatics 77: 18–28. Available: http://dx.doi.org/10.1002/prot.22561.Sponsors
Grant sponsor: The US National Library of Medicine (NIH/NLM); Grant number: LM-07085; Grant sponsor: KAUST Grant number: KUK-11-012-43; Grant sponsor: EMBO; Grant sponsor: Italbionet (MIUR).Publisher
WileyPubMed ID
19731382PubMed Central ID
PMC4589151ae974a485f413a2113503eed53cd6c53
10.1002/prot.22561
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