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    Evaluation of template-based models in CASP8 with standard measures

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    Type
    Article
    Authors
    Cozzetto, Domenico
    Kryshtafovych, Andriy cc
    Fidelis, Krzysztof cc
    Moult, John
    Rost, Burkhard
    Tramontano, Anna
    KAUST Grant Number
    KUK-11-012-43
    Date
    2009-08-05
    Online Publication Date
    2009-08-05
    Print Publication Date
    2009
    Permanent link to this record
    http://hdl.handle.net/10754/598255
    
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    Abstract
    The strategy for evaluating template-based models submitted to CASP has continuously evolved from CASP1 to CASP5, leading to a standard procedure that has been used in all subsequent editions. The established approach includes methods for calculating the quality of each individual model, for assigning scores based on the distribution of the results for each target and for computing the statistical significance of the differences in scores between prediction methods. These data are made available to the assessor of the template-based modeling category, who uses them as a starting point for further evaluations and analyses. This article describes the detailed workflow of the procedure, provides justifications for a number of choices that are customarily made for CASP data evaluation, and reports the results of the analysis of template-based predictions at CASP8.
    Citation
    Cozzetto D, Kryshtafovych A, Fidelis K, Moult J, Rost B, et al. (2009) Evaluation of template-based models in CASP8 with standard measures. Proteins: Structure, Function, and Bioinformatics 77: 18–28. Available: http://dx.doi.org/10.1002/prot.22561.
    Sponsors
    Grant sponsor: The US National Library of Medicine (NIH/NLM); Grant number: LM-07085; Grant sponsor: KAUST Grant number: KUK-11-012-43; Grant sponsor: EMBO; Grant sponsor: Italbionet (MIUR).
    Publisher
    Wiley
    Journal
    Proteins: Structure, Function, and Bioinformatics
    DOI
    10.1002/prot.22561
    PubMed ID
    19731382
    PubMed Central ID
    PMC4589151
    ae974a485f413a2113503eed53cd6c53
    10.1002/prot.22561
    Scopus Count
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