Enantiospecific kinking of DNA by a partially intercalating metal complex

Reymer, Anna; Nordén, Bengt

Enantiospecific kinking of DNA by a partially intercalating metal complex

Type

Article

Authors

Reymer, Anna
Nordén, Bengt

KAUST Grant Number

KUK-11-008-23

Date

2012

Abstract

Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.

Citation

Reymer A, Nordén B (2012) Enantiospecific kinking of DNA by a partially intercalating metal complex. Chem Commun 48: 4941. Available: http://dx.doi.org/10.1039/c2cc31176c.

Acknowledgements

This work was supported by King Abdullah University of Science and Technology, Grant [KUK-11-008-23] awarded to B.N.