Enantiospecific kinking of DNA by a partially intercalating metal complex

Type
Article
Authors
Reymer, Anna
Nordén, Bengt
KAUST Grant Number
KUK-11-008-23
Date
2012

Metadata
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Abstract
Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.
Citation
Reymer A, Nordén B (2012) Enantiospecific kinking of DNA by a partially intercalating metal complex. Chem Commun 48: 4941. Available: http://dx.doi.org/10.1039/c2cc31176c.
Sponsors
This work was supported by King Abdullah University of Science and Technology, Grant [KUK-11-008-23] awarded to B.N.
Publisher
Royal Society of Chemistry (RSC)
Journal
Chemical Communications
ISSN
1359-7345
1364-548X
DOI
10.1039/c2cc31176c
PubMed ID
22476247
Handle URI
http://hdl.handle.net/10754/598163
Collections
Publications Acknowledging KAUST Support