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dc.contributor.authorBaumgartner, Corinne
dc.contributor.authorMa, Sandy
dc.contributor.authorLiu, Qi
dc.contributor.authorStoltz, Brian M.
dc.date.accessioned2016-02-25T13:13:05Z
dc.date.available2016-02-25T13:13:05Z
dc.date.issued2010
dc.identifier.citationBaumgartner C, Ma S, Liu Q, Stoltz BM (2010) Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis. Org Biomol Chem 8: 2915. Available: http://dx.doi.org/10.1039/c004275g.
dc.identifier.issn1477-0520
dc.identifier.issn1477-0539
dc.identifier.pmid20498895
dc.identifier.doi10.1039/c004275g
dc.identifier.urihttp://hdl.handle.net/10754/598122
dc.description.abstractOur efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry. © 2010 The Royal Society of Chemistry.
dc.description.sponsorshipC. B. thanks the Schweizerischer Nationalfonds (SNF) for a fellowship. This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Additionally, the authors thank Abbott, Amgen, Boehringer-Ingelheim, Bristol-Myers Squibb, Merck, Sigma-Aldrich and Caltech for generous funding. Mr Lawrence Henling and Dr Michael Day are gratefully acknowledged for X-ray crystallographic structural determination. The Bruker KAPPA APEXII X-ray diffractometer was purchased via an NSF CRIF:MU award to the California Institute of Technology, CHE-0639094. Dr David VanderVelde and Dr Scott Ross are acknowledged for NMR assistance. Dr Scott Virgil is acknowledged for helpful discussions.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleEfforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis
dc.typeArticle
dc.identifier.journalOrganic & Biomolecular Chemistry
dc.contributor.institutionCalifornia Institute of Technology, Pasadena, United States
kaust.grant.numberKUS-11-006-02


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