Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis
| dc.contributor.author | Baumgartner, Corinne | |
| dc.contributor.author | Ma, Sandy | |
| dc.contributor.author | Liu, Qi | |
| dc.contributor.author | Stoltz, Brian M. | |
| dc.date.accessioned | 2016-02-25T13:13:05Z | |
| dc.date.available | 2016-02-25T13:13:05Z | |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Baumgartner C, Ma S, Liu Q, Stoltz BM (2010) Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis. Org Biomol Chem 8: 2915. Available: http://dx.doi.org/10.1039/c004275g. | |
| dc.identifier.issn | 1477-0520 | |
| dc.identifier.issn | 1477-0539 | |
| dc.identifier.pmid | 20498895 | |
| dc.identifier.doi | 10.1039/c004275g | |
| dc.identifier.uri | http://hdl.handle.net/10754/598122 | |
| dc.description.abstract | Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry. © 2010 The Royal Society of Chemistry. | |
| dc.description.sponsorship | C. B. thanks the Schweizerischer Nationalfonds (SNF) for a fellowship. This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Additionally, the authors thank Abbott, Amgen, Boehringer-Ingelheim, Bristol-Myers Squibb, Merck, Sigma-Aldrich and Caltech for generous funding. Mr Lawrence Henling and Dr Michael Day are gratefully acknowledged for X-ray crystallographic structural determination. The Bruker KAPPA APEXII X-ray diffractometer was purchased via an NSF CRIF:MU award to the California Institute of Technology, CHE-0639094. Dr David VanderVelde and Dr Scott Ross are acknowledged for NMR assistance. Dr Scott Virgil is acknowledged for helpful discussions. | |
| dc.publisher | Royal Society of Chemistry (RSC) | |
| dc.title | Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis | |
| dc.type | Article | |
| dc.identifier.journal | Organic & Biomolecular Chemistry | |
| dc.contributor.institution | California Institute of Technology, Pasadena, United States | |
| kaust.grant.number | KUS-11-006-02 |