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    Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

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    Type
    Article
    Authors
    Baumgartner, Corinne
    Ma, Sandy
    Liu, Qi
    Stoltz, Brian M.
    KAUST Grant Number
    KUS-11-006-02
    Date
    2010
    Permanent link to this record
    http://hdl.handle.net/10754/598122
    
    Metadata
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    Abstract
    Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry. © 2010 The Royal Society of Chemistry.
    Citation
    Baumgartner C, Ma S, Liu Q, Stoltz BM (2010) Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis. Org Biomol Chem 8: 2915. Available: http://dx.doi.org/10.1039/c004275g.
    Sponsors
    C. B. thanks the Schweizerischer Nationalfonds (SNF) for a fellowship. This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Additionally, the authors thank Abbott, Amgen, Boehringer-Ingelheim, Bristol-Myers Squibb, Merck, Sigma-Aldrich and Caltech for generous funding. Mr Lawrence Henling and Dr Michael Day are gratefully acknowledged for X-ray crystallographic structural determination. The Bruker KAPPA APEXII X-ray diffractometer was purchased via an NSF CRIF:MU award to the California Institute of Technology, CHE-0639094. Dr David VanderVelde and Dr Scott Ross are acknowledged for NMR assistance. Dr Scott Virgil is acknowledged for helpful discussions.
    Publisher
    Royal Society of Chemistry (RSC)
    Journal
    Organic & Biomolecular Chemistry
    DOI
    10.1039/c004275g
    PubMed ID
    20498895
    ae974a485f413a2113503eed53cd6c53
    10.1039/c004275g
    Scopus Count
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