DNA Duplex Length and Salt Concentration Dependence of Enthalpy−Entropy Compensation Parameters for DNA Melting

Type
Article

Authors
Starikov, E. B.
Nordén, Bengt

Date
2009-08-20

Abstract
Systematical differential calorimetry experiments on DNA oligomers with different lengths and placed in water solutions with various added salt concentrations may, in principle, unravel important information about the structure and dynamics of the DNA and their water-counterion surrounding. With this in mind, to reinterpret the most recent results of calorimetric experiments on DNA oligomers of such a kind, the recent enthalpy-entropy compensation theory has been used. It is demonstrated that the application of the latter could enable direct estimation of thermodynamic parameters of the microphase transitions connected to the changes in DNA dynamical regimes versus the length of the biopolymers and the ionic strengths of their water solutions, and this calls for much more systematical experimental and theoretical studies in this field. © 2009 American Chemical Society.

Citation
Starikov EB, Nordén B (2009) DNA Duplex Length and Salt Concentration Dependence of Enthalpy−Entropy Compensation Parameters for DNA Melting. J Phys Chem B 113: 11375–11377. Available: http://dx.doi.org/10.1021/jp903924j.

Acknowledgements
B.N. gratefully acknowledges the Award of 2008 from King Abdullah University of Science and Technology.

Publisher
American Chemical Society (ACS)

Journal
The Journal of Physical Chemistry B

DOI
10.1021/jp903924j

PubMed ID
19719257

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