Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device

Abstract
We demonstrate an implantable MEMS drug delivery device to conduct controlled and on-demand, ex vivo drug transport to human eye tissue. Remotely operated drug delivery to human post-mortem eyes was performed via a MEMS device. The developed curved packaging cover conforms to the eyeball thereby preventing the eye tissue from contacting the actuating membrane. By pulsed operation of the device, using an externally applied magnetic field, the drug released from the device accumulates in a cavity adjacent to the tissue. As such, docetaxel (DTX), an antiangiogenic drug, diffuses through the eye tissue, from sclera and choroid to retina. DTX uptake by sclera and choroid were measured to be 1.93±0.66 and 7.24±0.37 μg/g tissue, respectively, after two hours in pulsed operation mode (10s on/off cycles) at 23°C. During this period, a total amount of 192 ng DTX diffused into the exposed tissue. This MEMS device shows great potential for the treatment of ocular posterior segment diseases such as diabetic retinopathy by introducing a novel way of drug administration to the eye. © 2013 IEEE.

Citation
Pirmoradi FN, Ou K, Jackson JK, Letchford K, Cui J, et al. (2013) Controlled delivery of antiangiogenic drug to human eye tissue using a MEMS device. 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). Available: http://dx.doi.org/10.1109/MEMSYS.2013.6474161.

Acknowledgements
This work was funded in part by the CollaborativeHealth Research Projects, Natural Science andEngineering Research Council of Canada, the CanadianInstitutes of Health Research, and an AcademicExcellence Alliance grant awarded by the KAUST Officeof Competitive Research Funds. Mu Chiao is supportedby the Canada Research Chairs Program. Authors wouldlike to thank Mr. Tom Brubaker and Ms. Kye Lee,undergraduate students in the Lin lab, for their assistance.

Publisher
Institute of Electrical and Electronics Engineers (IEEE)

Journal
2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS)

DOI
10.1109/MEMSYS.2013.6474161

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