Show simple item record

dc.contributor.authorChen, Lianguo
dc.contributor.authorYe, Rui
dc.contributor.authorXu, Ying
dc.contributor.authorGao, Zhaoming
dc.contributor.authorAu, Doris W.T.
dc.contributor.authorQian, Pei-Yuan
dc.date.accessioned2016-02-25T12:57:01Z
dc.date.available2016-02-25T12:57:01Z
dc.date.issued2014-04
dc.identifier.citationChen L, Ye R, Xu Y, Gao Z, Au DWT, et al. (2014) Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma). Aquatic Toxicology 149: 116–125. Available: http://dx.doi.org/10.1016/j.aquatox.2014.01.023.
dc.identifier.issn0166-445X
dc.identifier.pmid24583292
dc.identifier.doi10.1016/j.aquatox.2014.01.023
dc.identifier.urihttp://hdl.handle.net/10754/597805
dc.description.abstractThis study evaluated the potential adverse effects of butenolide, a promising antifouling compound, using the marine medaka (Oryzias melastigma), a model fish for marine ecotoxicology. The active ingredient used in the commercial antifoulant SeaNine 211, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) was employed as the positive control. Adult marine medaka (4-month-old) were exposed to various concentrations of butenolide or DCOIT for 28 days and then depurated in clean seawater for 14 days (recovery). A suite of sensitive biomarkers, including hepatic oxidative stress, neuronal signal transmission, endocrine disruption, and reproductive function, was used to measure significant biological effects induced by the chemicals. Compared to DCOIT, chronic exposure to butenolide induced a lower extent of oxidative stress in the liver of male and female medaka. Furthermore, butenolide-exposed fish could recover faster from oxidative stress than fish exposed to DCOIT. Regarding neurotransmission, DCOIT significantly inhibited acetylcholinesterase (AChE) activity in the brain of both male and female medaka, whereas this was not significant for butenolide. In addition, plasma estradiol (E2) level was elevated and testosterone (T) level was decreased in male medaka exposed to DCOIT. This greatly imbalanced sex hormones ratio (E2/T) in exposed males, indicating that DCOIT is a potent endocrine disruptive chemical. In contrast, butenolide induced only moderate effects on sex hormone levels in exposed males, which could be gradually recovered during depuration. Moreover, the endocrine disruptive effect induced by butenolide did not affect normal development of offspring. In contrast, DCOIT-exposed fish exhibited a decrease of egg production and impaired reproductive success. Overall, the above findings demonstrated that chronic exposure to butenolide induced transient, reversible biological effect on marine medaka, while DCOIT could impair reproductive success of fish, as evident by clear alterations of the E2/T ratio. The relatively low toxicity of butenolide on marine biota highlights its promising application in the antifouling industry. The present findings also emphasize gender difference in fish susceptibility to chemical treatment (male>female), which is an important consideration for ecological risk assessment. © 2014 Elsevier B.V.
dc.description.sponsorshipThis study was supported by grants from China Mineral Resources Research and Development Association (COMRRDA12SC01) and from the Research Grant Council of HKSAR government (662413), and the King Abdullah University of Science and Technology (SA-C0040/UK-C0016) and the State Key Laboratory in Marine Pollution, City University of Hong Kong.
dc.publisherElsevier BV
dc.subjectAntifouling
dc.subjectButenolide
dc.subjectDCOIT
dc.subjectEndocrine disruption
dc.subjectMarine medaka
dc.titleComparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma)
dc.typeArticle
dc.identifier.journalAquatic Toxicology
dc.contributor.institutionHong Kong University of Science and Technology, Hong Kong, China
dc.contributor.institutionCity University of Hong Kong, Hong Kong, China
kaust.grant.numberSA-C0040
kaust.grant.numberUK-C0016


This item appears in the following Collection(s)

Show simple item record