KAUST Grant NumberKUK-C1-013-04
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AbstractColorectal cancer (CRC) has formed a canonical example of tumourigenesis ever since its use in Fearon and Vogelstein's linear model of genetic mutation, and continues to generate a huge amount of research interest. Over time, the field has witnessed a transition from solely experimental work to the inclusion of mathematical and computational modelling. The fusion of these disciplines has the potential to provide valuable insights into oncologic processes, but also presents the challenge of uniting many diverse perspectives. Furthermore, the cancer cell phenotype defined by the 'Hallmarks of Cancer' has been extended in recent times and provides an excellent basis for future research. The authors present a timely summary of the literature relating to CRC, addressing the traditional experimental findings, summarising the key mathematical and computational approaches, and emphasising the role of the Hallmarks in current and future developments. The authors conclude with a discussion of interdisciplinary work, outlining areas of experimental interest which would benefit from the insight that theoretical modelling can provide. © The institution of engineering and technology 2013.
CitationOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"><html> <head> <title>Current Links for doi: 10.1049/iet-syb.2012.0019</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><link rel="stylesheet" rev="stylesheet" type="text/css" href="/docs/iPage/css/iet_body.css"> </head> <body bgcolor="#FFFFFF"> <table width="57%"> <tr> <td><a href="http://www.theiet.org"><img src="/docs/iPage/images/iet.gif" alt="Institution of Engineering and Technology" border="0" align="left"></a></td></tr> <tr> <td><br/></td> </tr> <tr> <td>The IET is a world leading professional organisation sharing and advancing knowledge to promote science, engineering and technology across the world. <br> <hr> </td> </tr> </table> <table width="57%"> <tr> <td><tr><td><b>Colorectal cancer through simulation and experiment</b></td></tr><tr><td>Kershaw,Sophie K. et al.</td></tr><tr><td><i>IET Systems Biology</i>(2013),7(3):57</td></tr><tr><td><a href='http://dx.doi.org/10.1049/iet-syb.2012.0019'>http://dx.doi.org/10.1049/iet-syb.2012.0019</td></tr></td> <tr> <tr><td><hr></td></tr> </table> <table width="57%"> <tr> <td colspan="2"> This article is available from multiple sources. <b>Please click on the logo</b> of the service to which you have a subscription, or click any logo to obtain pay-per-view access.<br><br></td> </tr> <tr> <td width="35%"><a href="http://digital-library.theiet.org/content/journals/10.1049/iet-syb.2012.0019"><img src="/docs/iPage/images/idl.gif" border="0" alt="IET Digital Library on Scitation"></a></td> <td width="65%"><br> Access the IET Digital Library<br><br></td> </tr> <tr> <td><br/><br/></td> </tr> <tr> <td><a href="http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6531713"><img src="/docs/iPage/images/iel.gif" border="0" alt="IEL on IEEE Xplore"></a></td> <td><br> Access the IEL (IEEE/IET Electronic Library) on IEEE Xplore®</a><br><br></td></td> </tr> </table> </body></html>
SponsorsSKK is supported by an EPSRC-funded Systems Biology Doctoral Training Centre studentship and a Google Europe Scholarship. HMB: This publication was based on work supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). DJG is funded through the OCISB project (BB/D020190/1) and the Systems Biology Doctoral Training Centre (EP/G50029/1). JMO is supported by Microsoft Research UK and the Life Sciences Interface and Systems Biology Doctoral Training Centres, and the Systems Approaches to Biomedical Science Industrial Doctorate Centre (EP/E501605/1, EP/G50029/1 and EP/G037280/1, respectively).
JournalIET Systems Biology